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Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL

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貨號: 04-1046

品牌: Millipore

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Description
CatalogueNumber	04-1046
Description	Anti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,Rabbit\|04-1046
AlternateNames	Translocation-associatednotchproteinTAN-1 neurogeniclocusnotchhomologprotein1
BackgroundInformation	NotchisthereceptorforDeltaandJaggedligands,whichcauseproteolysisofnotchtoliberatetheintracellulardomain.ThatdomaintranslocatestothenucleusandinitiatestranscriptioneventsbybindingtheDNAbindingproteinCSL.Thenotchfamilymembersareinvolvedinnumerousdifferentiationandcelllineagedeterminationsteps.

ProductInformation
Format	Purified
Control	Hek293celllysates
Presentation	RabbitmonoclonalIgGinbuffercontaining50mMTris-Glycine(pH7.4),0.18MNaClcontaining40%Glycerol,0.25%sodiumazide,0.25mMEDTA,25mMCitricAcid,and0.5%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Anti-Notch1(Cytoplasmic)Antibody,cloneEP1238Y,RabbitdetectslevelofNotch1(Cytoplasmic)&hasbeenpublished&validatedforuseinWB,IC,IH.
KeyApplications	WesternBlotting Immunocytochemistry Immunohistochemistry
ApplicationNotes	ImmunohistochemistryAnalysis:1:50-100dilutionfromapreviouslotdetectedNotch1inHumanfetallungtissue.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtothecytoplasmicdomainofhumanNotch1
Epitope	CytoplasmicDomain
Clone	EP1238Y
Host	Rabbit
Specificity	ThisantibodyrecognizesthecytoplasmicdomainofNotch1
Isotype	IgG
SpeciesReactivity	Human Mouse
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_060087.3
EntrezGeneSummary	ThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.[providedbyRefSeq]
GeneSymbol	TAN1 hN1 notch1
UniProtNumber	P46531
UniProtSummary	FUNCTION:Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmanngliaBysimilarity. SUBUNITSTRUCTURE:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1.Ref.6Ref.7Ref.8 SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneproteinBysimilarity. Notch1intracellulardomain:NucleusBysimilarity.Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleusBysimilarity. TISSUESPECIFICTY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues. PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembraneBysimilarity. PhosphorylatedBysimilarity. INVOLVEMENTINDISEASE:NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.Ref.13 DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation. SEQUENCESIMILARITIES:BelongstotheNOTCHfamily. Contains5ANKrepeats. Contains36EGF-likedomains. Contains3LNR(Lin/Notch)repeats.
MolecularWeight	~125kDa

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Millipore/04-1046 | Anti-Notch1 (Cytoplasmic) Antibody, clone EP1238Y, Rabbit | 04-1046/04-1046/100 µL

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