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Millipore/04-1054 | Anti-S100-β (CT) Antibody, clone EP1576Y, rabbit monoclonal/04-1054/100 µL

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貨號: 04-1054

品牌: Millipore

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Description
CatalogueNumber	04-1054
Description	Anti-S100-β(CT)Antibody,cloneEP1576Y,rabbitmonoclonal
AlternateNames	S-100calcium-bindingprotein,betachain S-100proteinbetachain S-100proteinsubunitbeta S100beta S100calciumbindingproteinB S100calciumbindingprotein,beta(neural) S100calcium-bindingproteinB S100calcium-bindingprotein,beta S100calcium-bindingprotein,beta(neural)
BackgroundInformation	S-100proteinisamemberoftheEF-handcalcium-bindingproteinsuperfamilythatiswidelydistributedandconservedinthecentralnervoussystemofvertebrates.Theproteinexistsinbothheterodimericandhomodimericforms.ThetwosubunitsofS-100proteinaretheproductsofseparategenesthataredifferentiallyexpressedbyvariouscells.ThebetasubunitispresentinallS-100positivecellsandtumors.Incontrast,thealphasubunitisdetectableonlyinheart,skeletalmuscleandbrain.Inadditiontoitscalciumbindingproperties,S-100proteinhasahigh-affinitybindingsiteforzincandisinvolvedintheregulationofproteinphosphorylationinthebrain.Theproteinapparentlyplaysaroleincelldifferentiationandgrowth,cytoskeletalstructureandfunction,andhasbeenimplicatedinneuropathologicaldiseases.

ProductInformation
Format	Unpurified
Control	A375celllysate
Presentation	RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.DetectS100-β(C-term)usingthisAnti-S100-β(C-term)Antibody,cloneEP1576Y,RabbitvalidatedforuseinWB,IH(P)&IP.
KeyApplications	WesternBlotting Immunohistochemistry(Paraffin) Immunoprecipitation
ApplicationNotes	ImmunohistochemistryAnalysis:A1:100-250dilutionfromapreviouslotdetectedS100-βinhumanmelanomatissue. ImmunoprecipitationAnalysis:A1:40dilutionfromapreviouslotwasusedinIP.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtoresiduesontheC-terminusofhumanS100-β.
Epitope	C-terminus
Clone	EP1576Y
Host	Rabbit
Specificity	ThisantibodyrecognizesS100-βatandaroundtheC-terminus.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_006263.1
EntrezGeneSummary	TheproteinencodedbythisgeneisamemberoftheS100familyofproteinscontaining2EF-handcalcium-bindingmotifs.S100proteinsarelocalizedinthecytoplasmand/ornucleusofawiderangeofcells,andinvolvedintheregulationofanumberofcellularprocessessuchascellcycleprogressionanddifferentiation.S100genesincludeatleast13memberswhicharelocatedasaclusteronchromosome1q21;however,thisgeneislocatedat21q22.3.ThisproteinmayfunctioninNeuriteextension,proliferationofmelanomacells,stimulationofCa2+fluxes,inhibitionofPKC-mediatedphosphorylation,astrocytosisandaxonalproliferation,andinhibitionofmicrotubuleassembly.Chromosomalrearrangementsandalteredexpressionofthisgenehavebeenimplicatedinseveralneurological,neoplastic,andothertypesofdiseases,includingAlzheimer"sdisease,Down"ssyndrome,epilepsy,amyotrophiclateralsclerosis,melanoma,andtypeIdiabetes.
GeneSymbol	NEF OTTHUMP00000174958 S100 S100beta
PurificationMethod	Unpurified
UniProtNumber	P04271
UniProtSummary	FUNCTION:Weaklybindscalciumbutbindszincverytightly-distinctbindingsiteswithdifferentaffinitiesexistforbothionsoneachmonomer.Physiologicalconcentrationsofpotassiumionantagonizethebindingofbothdivalentcations,especiallyaffectinghigh-affinitycalcium-bindingsites.BindstoandinitiatestheactivationofSTK38byreleasingautoinhibitoryintramolecularinteractionswithinthekinase. SUBUNITSTRUCTURE:Dimerofeithertwoalphachains,ortwobetachains,oronealphaandonebetachain.TheS100BdimerbindstwomoleculesofSTK38Bysimilarity.TheS100BdimerinteractswithtwomoleculesofCAPZA1. SUBCELLULARLOCATION:Cytoplasm.Nucleus. TISSUESPECIFICITY:Althoughpredominantamongthewater-solublebrainproteins,S100isalsofoundinavarietyofothertissues. MISCELLANEOUS:Inadditiontometal-ionbinding,thisproteinisinvolvedwiththeregulationofproteinphosphorylationinbraintissue. SEQUENCESIMILARITIES:BelongstotheS-101family. Contains2EF-handdomains.
MolecularWeight	~11kDa

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Millipore/04-1054 | Anti-S100-β (CT) Antibody, clone EP1576Y, rabbit monoclonal/04-1054/100 µL

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