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Millipore/04-1070 | Anti-phospho-β-Catenin(Ser33/Ser37) Antibody, clone EP742(2)Y, rabbit monoclonal/04-1070/100 µ

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貨號: 04-1070

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Description
CatalogueNumber	04-1070
Description	Anti-phospho-β-Catenin(Ser33/Ser37)Antibody,cloneEP742(2)Y,rabbitmonoclonal
AlternateNames	catenin(cadherin-associatedprotein),beta1(88kD) catenin(cadherin-associatedprotein),beta1,88kDa cateninbeta-1
BackgroundInformation	β-CateninlinksCadherincelladhesionproteinstotheCytoskeletonandhasrecentlybeenimplicatedintheWnt/Winglesssignalingpathwayandintheprogressionofneoplasia.β-CateninassociateswiththetumorsuppressorAdenomatousPolypopsisColi(APC)andfunctionsasaco-activatoroftheTCFtranscriptionfactorfamily.ItisregulatedbyGlycogenSynthaseKinase(GSK)3b,whichphosphorylatesandtargetsβ-Cateninforubiquitin-mediatedproteolysis.StABIlizationofβ-Catenin,eitherbyWnt-mediatedinhibitionofGSK3borbymutation(asfoundinnumerouscolorectaltumorsandmelanomacelllines),resultsinactivationofTCFresponsivegeneswhicharethoughttoplaykeyrolesindevelopmentandcancerprogression.δ-Catenin(NPRAP/Neurojungin),amemberofthep120Cateninsubfamily,isastructuralproteininvolvedinneuronaldevelopment.ItinteractswithActin,CortactinandSrcKinasestopromoteneuriteelongationorbranching,dependinguponitsphosphorylationstate.

ProductInformation
Format	Unpurified
Control	293Tcelllysates
Presentation	RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:Variabilityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Detectphospho-β-Catenin(Ser33/Ser37)usingthisAnti-phospho-β-Catenin(Ser33/Ser37)Antibody,cloneEP742(2)Y,RabbitvalidatedforuseinWB.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	Phospho-specificpeptidecorrespondingtoresiduessurroundingSerine33andSerine37ofhumanβ-catenin.
Epitope	phospho-Ser33/Ser37
Clone	EP742(2)Y
Host	Rabbit
Specificity	Thisantibodydetectsβ-cateninphosphorylatedonSerine33and/orSerine37neartheN-terminus.
Isotype	IgG
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001091679.1
EntrezGeneSummary	Beta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactincytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM].
GeneSymbol	Beta-catenin CTNNB DKFZp686D02253 FLJ25606 FLJ37923 OTTHUMP00000165222 OTTHUMP00000165223
Modifications	Phosphorylation
PurificationMethod	Unpurified
UniProtNumber	P35222
UniProtSummary	FUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway. SUBUNITSTRUCTURE:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.Thestabilizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andCHD8.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1bindingBysimilarity.InteractswithTAX1BP3(viathePDZdomain);thisinteractioninhibitsthetranscriptionalactivityofCTNNB1Bysimilarity.InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2andMUC1.InteractswithSLC30A9.InteractswithXIRP1Bysimilarity.InteractswithPTPRU(viathecytoplasmicjuxtamembranedomain). SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cytoplasm?cytoskeleton.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2andMUC1promotesnucleartranslocation. TISSUESPECIFICITY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon. PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33. EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding. UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1XProbable.Itsubiquitinationleadstoitssubsequentproteasomaldegradation. DISEASE:ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife. DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor. DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren. AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1. SIMILARITY:Belongstothebeta-cateninfamily. Contains12ARMrepeats.
MolecularWeight	~92kDa

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Millipore/04-1070 | Anti-phospho-β-Catenin(Ser33/Ser37) Antibody, clone EP742(2)Y, rabbit monoclonal/04-1070/100 µ

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