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Millipore/04-1075 | Anti-phospho-GSK3 β (Ser9) Antibody, clone EPR2286Y, rabbit monoclonal/04-1075/100 µL

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貨號: 04-1075

品牌: Millipore

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Description
CatalogueNumber	04-1075
Description	Anti-phospho-GSK3β(Ser9)Antibody,cloneEPR2286Y,rabbitmonoclonal
AlternateNames	GSK-3beta GSK3betaisoform glycogensynthasekinase3beta glycogensynthasekinase-3beta
BackgroundInformation	GSK3(GlycogenSynthaseKinase3)differsfrommostserine/threoninekinasesinthatitisactiveintheabsenceoftheactionofsignalingpathways.Twoisoformsexist,GSK3αandGSK3β.ThefunctionofGSK3istophosphorylateGlycogenSynthaseandtherebyinactivateit.InsulinactionstimulatesthePI3Kinasepathway,resultinginAktactivation,whichphosphorylatesandinactivatesGSK3.GlycogenSynthaseisthenrapidlydephosphorylatedandactivated.OtherGSK3substratesincludeJun(oninhibitorysites),andeIF2B.PhosphorylationofTaubyGSK3mayrelatetodevelopmentofAlzheimer"sdisease.Phosphorylationstate-specificantibodiesdirectedagainsttheAktsite(Ser21)onGSK3aresuitableforsurrogateassaysoftheactivationstateofthepathway.

ProductInformation
Format	Unpurified
Control	293Tcelllysate
Presentation	RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance. Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Detectphospho-GSK3β(Ser9)usingthisAnti-phospho-GSK3β(Ser9)Antibody,cloneEPR2286Y,RabbitvalidatedforuseinWB,IH(P)&IC.
KeyApplications	WesternBlotting Immunohistochemistry(Paraffin) Immunocytochemistry
ApplicationNotes	ImmunohistochemistryAnalysis:A1:100-250dilutionfromapreviouslotdetectedGSK3βinhumanovariancarcinomatissue. ImmunocytochemistryAnalysis:A1:100-250dilutionfromapreviouslotworkedinIC.

BIOLOGicalInformation
Immunogen	Phospho-specificpeptidecorrespondingtoresiduessurroundingSer9ofhumanGSK3β.
Epitope	PhosphorylatedSer9
Clone	EPR2286Y
Host	Rabbit
Specificity	TheantibodyonlydetectsGSK3βphosphorylatedonSer9.
Isotype	IgG
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_002084.2
EntrezGeneSummary	Glycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandinactivatingglycogensynthase(seeGYS1,MIM138570).Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).
GeneSymbol	EC2.7.11.26
Modifications	Phosphorylation
PurificationMethod	Unpurified
UniProtNumber	P49841
UniProtSummary	FUNCTION:ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.PhosphorylatesMUC1inbreastcancercells,anddecreasestheinteractionofMUC1withCTNNB1/beta-catenin.Ref.5 CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ENZYMEREGULATION:InhibitedwhenphosphorylatedbyAKT1. SUBUNITSTRUCTURE:MonomerBysimilarity.InteractswithCABYR,MUC1,NINandPRUNE. TISSUESPECIFICITY:Expressedintestis,thymus,prostateandovaryandweaklyexpressedinlung,brainandkidney. PTM:PhosphorylatedbyAKT1andILK1. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily. Contains1proteinkinasedomain.
MolecularWeight	~47kDa

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Millipore/04-1075 | Anti-phospho-GSK3 β (Ser9) Antibody, clone EPR2286Y, rabbit monoclonal/04-1075/100 µL

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