當前位置： Millipore >>> Millipore/04-1091 | Anti-Sir2/SIRT1 Antibody, clone E104, rabbit monoclonal/04-1091/100 µL

Millipore/04-1091 | Anti-Sir2/SIRT1 Antibody, clone E104, rabbit monoclonal/04-1091/100 µL

價格: 試用市場價: 0.00

打印產品信息

貨號: 04-1091

品牌: Millipore

規格

默認

數量

庫存(0)

特別提示

代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯系客服核對商品價格，訂單生效后再付款。

立即申請

收藏商品

資深產品顧問

咨詢顧問

全國免費服務熱線

4000-520-616

自營商城一站式服務
廠家直采剔除溢價
品質甄選正品保證
嚴控流程只做188精品
極速物流如約送貨

詳情
使用說明
常見問題

Description
CatalogueNumber	04-1091
Description	Anti-Sir2/SIRT1Antibody,cloneE104,rabbitmonoclonal
AlternateNames	SIR2-likeprotein2 silencinginformationregulator2-like silentinformationregulator2 sir2-relatedproteintype2 sirtuin(silentmatingtypeinformationregulation2 homolog)2(S.cerevisiae) sirtuin(silentmatingtypeinformationregulation2, S.cerevisiae,homolog)2 sirtuin2 sirtuintype2
BackgroundInformation	Sir2isshortforSilentmatingtypeInformationRegulation-2.Sir2(whosehomologinmammalsisknownasSIRT1,SIR2L1orSir2α)isthenamesakeofafamilyofcloselyrelatedenzymes,thesirtuins.Membersofthisfamilyhavebeenfoundinnearlyallorganismsstudied.Sirtuinsarehypothesizedtoplayakeyroleinanorganism"sresponsetostresses(suchasheatorstarvation)andtoberesponsIBLefortheLifespan-extendingeffectsofcalorierestriction.SirtuinsactbyremovingacetylgroupsfromproteinsinthepresenceofNAD+;theyarethusclassifiedas"NAD+-dependentdeacetylases".Inmammals,SIRT1(themammalianhomologofSir2)hasbeenshowntodeacetylateandtherebydeactivatethep53protein.

ProductInformation
Format	Unpurified
Control	Jurkatcelllysate
Presentation	RabbitMonoclonalinbuffercontaining50mMTris-Glycine(pH7.4),0.15MNaClcontaining40%Glycerol,0.01%sodiumazideand0.05%BSA.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt.HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.
KeyApplications	Immunoprecipitation WesternBlotting Immunocytochemistry Immunohistochemistry(Paraffin)
ApplicationNotes	ImmunohistochemistryAnalysis:A1:100-250dilutionfromapreviouslotdetectedSir2inhumancolonandlungsquamouscarcinomatissue. ImmunocytochemistryAnalysis:A1:100-250dilutionfromapreviouslotwasusedinIC. ImmunoprecipitationAnalysis:A1:50dilutionfromapreviouslotwasusedinIP.

BIOLOGicalInformation
Immunogen	SyntheticpeptidecorrespondingtoresiduesnearC-terminusandbeforeAla-richdomainofhumanSir2.
Epitope	C-terminus
Clone	E104
Host	Rabbit
Specificity	Theantibodydoesnotcross-reactwithothersirtuinfamilymembers.
Isotype	IgG
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001135970.1
EntrezGeneSummary	Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Alternativesplicingresultsinmultipletranscriptvariants.
GeneSymbol	EC3.5.1.- SIR2 SIR2-like SIR2L SIR2L2
PurificationMethod	Unpurified
UniProtNumber	Q8IXJ6
UniProtSummary	FUNCTION:NAD-dependentdeacetylase,whichdeacetylatesthe"Lys-40"ofalpha-tubulin.Involvedinthecontrolofmitoticexitinthecellcycle,probablyviaitsroleintheregulationofCytoskeleton.Despitesomeabilitytodeacetylatehistonesinvitro,itisunlikelyinvivo. CATALYTICACTIVITY:NAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein. COFACTOR:Binds1zincionpersubunit. ENZYMEREGULATION:InhibitedbySirtinol,A3andM15smallmolecules.Inhibitedbynicotinamide. SUBUNITSTRUCTURE:InteractswithHDAC6,suggestingthattheseproteinsbelongtoalargecomplexthatdeacetylatethecytoskeleton. SUBCELLULARLOCATION:Cytoplasm?cytoskeleton.Note:Colocalizeswithmicrotubules. TISSUESPECIFICITY:Widelyexpressed.Highlyexpressedinheart,brainandskeletalmuscle,whileitisweaklyexpressedinplacentaandlung.Down-regulatedinmanygliomassuggestingthatitmayactasatumorsuppressorgeneinhumangliomaspossiblythroughtheregulationofmicrotubulenetwork. DEVELOPMENTALSTAGE:Peaksduringmitosis.Aftermitosis,itisprobablydegradedbythe26Sproteasome. PTM:PhosphorylatedattheG2/Mtransitionofthecellcycle. SEQUENCESIMILARITIES:Belongstothesirtuinfamily. Contains1deacetylasesirtuin-typedomain. SEQUENCECAUTION:ThesequenceAAF67015.1differsfromthatshown.Reason:Frameshiftatseveralpositions.
MolecularWeight	~110kDa

PhysicochemicalInformation

Dimensions

MaterialsInformation

MaterialsInformation

售后保障

螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。

Q：生物188產品正品保障嗎？
A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購，自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

Q：下單后可以修改訂單嗎？
A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

Q：可以開發票嗎？
A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

Q：商品幾天可以發貨？
A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

Q：如何聯系商家？
A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

Q：收到的商品少了/發錯了怎么辦？
A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

Q：退換貨/維修需要多長時間？
A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

24小時熱銷榜

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
￥830.00
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
￥830.00
Qubit? dsDNA BR Assay Kit Q32853現貨
￥2000.00
Parafilm M封口膜/PM996/4x125/整箱
￥1296.00

Millipore/04-1091 | Anti-Sir2/SIRT1 Antibody, clone E104, rabbit monoclonal/04-1091/100 µL

客戶服務

何為188

關注188微信公眾號