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Millipore/04-218 | Anti-CREB Antibody, clone E306, rabbit monoclonal/04-218/100 µL

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貨號: 04-218

品牌: Millipore

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Description
CatalogueNumber	04-218
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-CREBAntibody,cloneE306,rabbitmonoclonal
AlternateNames	cAMPresponsiveelementbindingprotein activetranscriptionfactorCREB transactivatorprotein
BackgroundInformation	CREB,cyclicAMP(cAMP)responseelement-bindingprotein,isaubiquitouslyexpressedbasicleucinezippertranscriptionfactorthatfunctionsinglucosehomeostasisandstimulatestheexpressionofnumerousgenesinresponsetogrowthfactors,hormones,neurotransmitters,ionfluxes,stresssignals,andhasbeenimplicatedinmemorybecauseifitsapparentroleinsynapticplasticity.CREBfunctionseitherbyitselforwithrelatedfamilymembers,whichincludeCREB,CREM,andATF-1,byforminghomo-andheterodimersthroughtheirbasicleucinezipper(bZIP)domains.TheCREBsignalingpathwayisactivatedbyextracellularligandsthatbindtocellsurfacereceptorsandrelaytheirmessagethroughvariousintracellularsecondmessengersresultingultimatelyintheactivationofnuclearCREBthroughphosphorylationofthetransactivationdomainatserine1332,4.TheclassicalmodelofCREBactivationisthroughPKA(cAMP-dependentproteinkinase).Inthenon-activestate,PKAresidesinthecytoplasmasaninactiveheterotetramerofpairedregulatoryandcatalyticsubunits.StimulationofcAMPcausesthereleasesofthecatalyticsubunitsofPKAthatpassivelydiffuseintothenucleusandinitiatesgeneexpressionbyphosphorylatingCREBatitstransactivationdomainonserine1331,2,3,4.CREBmediatestheactivationofcAMP-responsivegenesbybindingasadimertoaconservedcAMP-responsiveelement(CRE),5’-TGACGTCA-3’,locatedwithinthepromoterregionoftargetgenes.Targetgeneactivationisterminatedbytheserine/threoninephosphatasesPP-1-mediateddephospho-rylationofCREB.

ProductInformation
Format	CultureSupernatant
Control	A431wholecelllysate.
Presentation	100μLofrabbitmonoclonalIgGin60%storagebuffer(50mMTris-Glycine(pH7.4),0.15MNaCl,0.01%sodiumazideand0.05%BSA)and40%glycerol.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	PleasenotethatthisproductwillnotbeavailableforsaleafterMarch15,2015.Pleaseselectoneoftheotherantibodiesagainstthistarget.Anti-CREBAntibody,cloneE306,rabbitdetectslevelofCREB&hasbeenpublished&validatedforuseinFC,IC,IF,IH(P),IP&WB.
KeyApplications	FlowCytometry Immunocytochemistry Immunofluorescence Immunohistochemistry(Paraffin) Immunoprecipitation WesternBlotting
ApplicationNotes	FlowCytometry:1:40dilutionfromapreviouslotwasusedonflowcytometry. Immunohistochemistry:1:250-500dilutionfromapreviouslotwasusedonimmunohistochemistry. Immunoprecipitation:1:80dilutionfromapreviouslotwasusedonimmunoprecipitation. Immunocytochemistry:1:250-500dilutionfromapreviouslotwasusedonimmunocytochemistry.

BIOLOGicalInformation
Immunogen	KLHconjugatedtoCREBlinearpeptide.
Epitope	Internal
Clone	E306
Host	Rabbit
Specificity	ThisantibodyrecognizesCREB.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Proventoreactwithhuman,ratandmouse.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_004379
GeneSymbol	MGC9284 CREB
UniProtNumber	P16220
UniProtSummary	Function:ThisproteinbindsthecAMPresponseelement(CRE),asequencepresentinmanyviralandcellularpromoters.CREBstimulatestranscriptiononbindingtotheCRE.TransciptionactivationisenhancedbytheTORCcoactivatorswhichactindependentlyofSer-133phosphorylation.ImplicatedinsynchronizationofcircADIanrhythmicity. Subunitstructure:InteractswithPPRC1.BindsDNAasadimer.Thisdimerisstabilizedbymagnesiumions.Interacts,throughthebZIPdomain,withthecoactivatorsTORC1/CRTC1,TORC2/CRTC2andTORC3/CRTC3.WhenphosphorylatedonSer-133,bindsCREBBPBysimilarity. Subcellularlocation:Nucleus. Post-translationalmodification:Stimulatedbyphosphorylation.PhosphorylationofbothSer-133andSer-142intheSCNregulatestheactivityofCREBandparticipatesincircadianrhythmgeneration.PhosphorylationofSer-133allowsCREBBPbindingBysimilarity.PhosphorylateduponDNAdamage,probablybyATMorATR. Sequencesimilarities:BelongstothebZIPfamily. Contains1bZIPdomain. Contains1KID(kinase-inducIBLe)domain.
MolecularWeight	~43kDa

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Millipore/04-218 | Anti-CREB Antibody, clone E306, rabbit monoclonal/04-218/100 µL

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