| Immunogen | KLH-conjugatedsyntheticpeptidecomposedofresiduesattheN-terminusofhumanCaspase-7. | 
| Host | Rabbit | 
| Specificity | RecognizesaregioncomposedofresiduesattheN-terminusofhumanCaspase-7. | 
| Isotype | IgG | 
| SpeciesReactivity |  | 
| AntibodyType | MonoclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Theprecursorofthiscaspaseiscleavedbycaspase3and10.Itisactivateduponcelldeathstimuliandinducesapoptosis.Alternativesplicingresultsinfourtranscriptvariants,encodingthreedistinctisoforms. | 
| GeneSymbol | CASP7CASP-7ICE-LAP3CMH-1MCH3
 | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:P55210#InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavesandactivatessterolregulatoryelementbindingproteins(SREBPs).Proteolyticallycleavespoly(ADP-ribose)polymerase(PARP)ata"216-Asp--Gly-217"bond.Overexpressionpromotesprogrammedcelldeath. SIZE:303aminoacids;34277Da
 SUBUNIT:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya20kDa(p20)anda11kDa(p11)subunit.
 SUBCELLULARLOCATION:Cytoplasm.
 TISSUESPECIFICITY:Highlyexpressedinlung,skeletalmuscle,liver,kidney,spleenandheart,andmoderatelyintestis.Noexpressioninthebrain.
 PTM:CleavagesbygranzymeBorcaspase-10generatethetwoactivesubunits.Propeptidedomainscanalsobecleavedefficientlybycaspase-3.Activeheterodimersbetweenthesmallsubunitofcaspase-7andthelargesubunitofcaspase-3,andviceversa,alsooccur.
 SIMILARITY:SwissProt:P55210##BelongstothepeptidaseC14family.
 | 
| MolecularWeight | 34kDa |