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Millipore/04-775 | Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal/04-775/100 µL

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貨號: 04-775

品牌: Millipore

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Description
CatalogueNumber	04-775
Replaces	05-775
Description	Anti-Ha-RasAntibody,cloneMC57,rabbitmonoclonal
AlternateNames	GTP-andGDP-bindingpeptideB GTPaseHRas Ha-Ras1proto-oncoprotein RasfamilysmallGTPbindingproteinH-Ras Transformingproteinp21 c-has/basp21protein c-ras-Ki-2activatedoncogene p19H-RasIDXprotein transformationgene:oncogeneHAMSV v-Ha-rasHarveyratsarcomaviraloncogenehomolog
BackgroundInformation	RasproteinsaresmallGTP-bindingproteinswhich,unliketheheterotrimericG-proteins,containallGTPaseandeffectorfunctionswithinasinglepolypeptide.AtleastthreeisoformsofRasexist,Ki-Ras,Ha-RasandN-Ras,withdistinctexpressionpatternsbutsimilarsignalingactivity.Rasispalmitoylatedandfarnesylatedatthecarboxyterminus,anchoringitinthemembrane.Inrestingcells,RasisloadedwithGDP,andisactivatedsubsequenttogrowthfactorstimulationofreceptors,whichrecruitRasGuaninenucleotideExchangeFactorstotheplaneofthemembrane.ProximityofexchangefactorstotheRasproteinscausesreleaseofGDP,anditsreplacementbyGTP.InitsGTP-boundform,Rasbindsseveralproteins,includingRaf,RalGDSandPI3Kinase.InactivationofRasoccursbyGTPhydrolysis,whichisgreatlyacceleratedbyRasGAPorNF-1,twoknownRasGTPaseActivatingProteins.ItispossIBLetoassayforRasactivationbyincubationoflysateswiththeRas-bindingdomainofRaf-1,whichselectivelybindstoRas:GTP.

ProductInformation
Format	CultureSupernatant
Control	IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431lysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
Presentation	Culturedsupernantantcontaining0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	DetectHa-RasusingthisAnti-Ha-RasAntibody,cloneMC57validatedforuseinWB.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	GSTfusionproteincorrespondingtofulllengthhumanHa-Ras.CloneMC57.
Clone	MC57
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	RecognizesHa-Ras,Mr~21kDa.DoesnotcrossreactwithCdc42,RhoorRac1.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Human.Predictedtocross-reactwithmouseandratbasedonsequencehomology.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_005334.1
EntrezGeneSummary	ThisgenebelongstotheRasoncogenefamily,whosemembersarerelatedtothetransforminggenesofmammaliansarcomaretroviruses.Theproductsencodedbythesegenesfunctioninsignaltransductionpathways.TheseproteinscanbindGTPandGDP,andtheyhaveintrinsicGTPaseactivity.Thisproteinundergoesacontinuouscycleofde-andre-palmitoylation,whichregulatesitsrapidexchangebetweentheplasmamembraneandtheGolgiapparatus.MutationsinthisgenecauseCostellosyndrome,adisease characterizedbyincreasedgrowthattheprenatalstage,growthdeficiencyatthepostnatalstage,predispositiontotumorformation,mentalretardation,skinandmusculoskeletalabnormalities,distinctivefacialappearanceandcardiovascularabnormalities.Defectsinthisgeneareimplicatedinavarietyofcancers,includingbladdercancer,follicularthyroidcancer,andoralsquamouscellcarcinoma.Multipletranscriptvariants,whichencodedifferentisoforms,havebeenidentifiedforthisgene.
GeneSymbol	C-BAS/HAS C-H-RAS C-HA-RAS1 CTLO H-RASIDX H-Ras-1 HAMSV HRAS1 Ha-Ras K-RAS N-RAS OTTHUMP00000162769 OTTHUMP00000166053 OTTHUMP00000166055 RASH1 c-H-ras p21ras
UniProtNumber	P01112
UniProtSummary	FUNCTION:RasproteinsbindGDP/GTPandpossessintrinsicGTPaseactivity.Ref.18Ref.32 ENZYMEREGULATION:AlternatebetweenaninactiveformboundtoGDPandanactiveformboundtoGTP.Activatedbyaguaninenucleotide-exchangefactor(GEF)andinactivatedbyaGTPase-activatingprotein(GAP). SUBUNITSTRUCTURE:InitsGTP-boundforminteractswithPLCE1.InteractswithTBC1D10C.InteractswithRGL3Bysimilarity.FormsasignalingcomplexwithRASGRP1andDGKZ.InteractswithRASSF5. SUBCELLULARLOCATION:Cellmembrane;Lipid-anchor;Cytoplasmicside.Golgiapparatusmembrane;Lipid-anchor.Note:ShuttlesbetweentheplasmamembraneandtheGolgiapparatus. PTM:PalmitoylatedbytheZDHHC9-GOLGA7complex.Acontinuouscycleofde-andre-palmitoylationregulatesrapidexchangebetweenplasmamembraneandGolgi.S-nitrosylated;criticalforredoxregulation.Importantforstimulatingguaninenucleotideexchange.Nostructuralperturbationonnitrosylation. INVOLVEMENTINDISEASE:DefectsinHRASarethecauseofCostellosyndrome[MIM:218040];alsoknownasfaciocutaneoskeletalsyndrome.Costellosyndromeisarareconditioncharacterizedbyprenatallyincreasedgrowth,postnatalgrowthdeficiency,mentalretardation,distinctivefacialappearance,cardiovascularabnormalities(typicallypulmonicstenosis,hypertrophiccardiomyopathyand/oratrialtachycardia),tumorpredisposition,skinandmusculoskeletalabnormalities. DefectsinHRASarethecauseofcongenitalmyopathywithexcessofmusclespindles(CMEMS)[MIM:218040].CMEMSisavariantofCostellosyndrome. DefectsinHRASmaybeacauseofsusceptibilitytoHurthlecellthyroidcarcinoma[MIM:607464];alsoknownasHurthlecellthyroidneoplasia.Hurthlecellthyroidcarcinomaaccountsforapproximately3%ofallthyroidcancers.Althoughtheyareclassifiedasvariantsoffollicularneoplasms,theyaremoreoftenmultifocalandsomewhatmoreaggressiveandarelesslikelytotakeupiodinethanareotherfollicularneoplasms.Mutationswhichchangepositions12,13or61activatethepotentialofHRAStotransformculturedcellsandareimplicatedinavarietyofhumantumors.DefectsinHRASareacauseofbladdercancer.DefectsinHRASarethecauseoforalsquamouscellcarcinoma(OSCC). SEQUENCESIMILARITIES:BelongstothesmallGTPasesuperfamily.Rasfamily. MASSSPECTROMETRY:Molecularmassis6.223±2Dafrompositions112-166.DeterminedbyESI.Molecularmassis6.253±2Dafrompositions112-166.DeterminedbyESI.Includesonenitricoxidemolecule.
MolecularWeight	~21kDa

PhysicochemicalInformation

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Millipore/04-775 | Anti-Ha-Ras Antibody, clone MC57, rabbit monoclonal/04-775/100 µL

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