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Millipore/05-1116 | Anti-VEGF Antibody, clone CH-10/05-1116/100 µg

價格: ￥3576.00 市場價: 5960.00

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貨號: 05-1116

品牌: Millipore

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Description
CatalogueNumber	05-1116
Replaces	MAB1665
Description	Anti-VEGFAntibody,cloneCH-10
AlternateNames	VascularpermeABIlityfactor vascularendothelialgrowthfactor vascularendothelialgrowthfactorA vascularendothelialgrowthfactorisoformVEGF165
BackgroundInformation	VEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.

ProductInformation
Format	AffinityPurified
Control	Jurkatcelllysate
Presentation	Liquidin20mMsodiumphosphate,250mMNaCl,pH.7.6containing0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	Anti-VEGFAntibody,cloneCH-10isanantibodyagainstVEGFforuseinWB.
KeyApplications	WesternBlotting

BiologicalInformation
Immunogen	RecombinantmouseVEGF.
Clone	CH-10
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	ThisantibodyrecognizeshumanandratVEGF,othervariantsnottested.
Isotype	IgG1
SpeciesReactivity	Human Rat
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_033531.3
EntrezGeneSummary	ThisgeneproductisamemberofthePDGF/VEGFgrowthfactorfamily.Itisamitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesis,endothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.Also,alternativetranslationinitiationfromnon-AUG(CUG)andAUGstartsitesinsometranscriptvariants,giverisetoadditionalisoforms.
GeneSymbol	MGC70609 MVCD1 VEGF VEGF-A VPF
PurificationMethod	AffinityPurfied
UniProtNumber	P15692
UniProtSummary	FUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145.IsoformVEGF165BbindstoVEGFR2/Kdrbutdoesn"tactivatedownstreamsignalingpathways,doesn"tactivateangiogenesisandinhibitstumorgrowth. SUBUNITSTRUCTURE:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGFBysimilarity. SUBCELLULARLOCATION:Secreted.Note:VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin. TISSUESPECIFICITY:TheVEGF189,VEGF-165andVEGF-121isoformsarewidelyexpressed,whereastheVEGF206andVEGF-145areuncommon. INDUCTION:Regulatedbygrowthfactors,cytokines,gonadotropins,nitricoxide,hypoxia,hypoglycemiaandoncogenicmutations. SEQUENCESIMILARITIES:BelongstothePDGF/VEGFgrowthfactorfamily. SEQUENCECAUTION:ThesequenceCAC19512.2differsfromthatshown.Reason:Erroneousgenemodelprediction.
MolecularWeight	12/16/19kDa

PhysicochemicalInformation

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MaterialsInformation

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Millipore/05-1116 | Anti-VEGF Antibody, clone CH-10/05-1116/100 µg

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