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Millipore/05-1232 | Anti-acetyl Histone H4 (Lys16) Antibody, clone 4E10.2/05-1232/100 µg

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貨號: 05-1232

品牌: Millipore

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Description
CatalogueNumber	05-1232
TradeName	Upstate
Description	Anti-acetylHistoneH4(Lys16)Antibody,clone4E10.2
AlternateNames	H4K16Ac HistoneH4(acetylK16) HIST1H4
BackgroundInformation	HistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonemodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).GloballossofacetylationatLys16isacommonhallmarkofhumantumorcells,suggestingaroleforacetylatedLys16inpreventingcelltransformation.Moreover,Lys16istheonlyhistonemarkthathasbeendirectlylinkedtochromatinrefoldingandmaintainenceofchromatinstructure.TheSir3proteinhelpsformtelomericheterochromatinbyinteractingwithhypoacetylatedhistoneH4Lys16whiletheMYST-likeacetyltransferaseSas2pisrequiredfortheacetylationH4-Lys16ineuchromatin.

ProductInformation
Format	Purified
Control	Sodiumbutyrate-treatedHeLacellacidextracts.
Presentation	PurifiedfromascitesbyproteinGchromatography.Suppliedat1mg/mlinPBS,0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt. Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.

Applications
Application	Anti-acetylHistoneH4(Lys16)Antibody,clone4E10.2isamousemonoclonalantibodyfordetectionofacetylHistoneH4(Lys16)alsoknownasH4K16Ac,HistoneH4(acetylK16),HIST1H4&hasbeenvalidatedinWB,PIA.
KeyApplications	WesternBlotting PeptideInhibitionAssay

BIOLOGicalInformation
Immunogen	KLH-conjugated,syntheticpeptidecontainingthesequence(GKGGA[acetyl-K]RHRKC,correspondingtothesequencesurroundingacetylatedlysine16ofhumanhistoneH4.
Epitope	AcetylLys16
Clone	4E10.2
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	RecognizeshistoneH4acetylatedonLys16,Mr11kDa.
Isotype	IgG1κ
SpeciesReactivity	Human
SpeciesReactivityNote	Basedonsequencehomology,broadspeciescross-reactivityisexpected.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_003529
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.[providedbyRefSeq].
Modifications	Acetylation
PurificationMethod	ProteinGPurified
UniProtNumber	P62805
UniProtSummary	FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. Subunitstructure:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. Subcellularlocation:Nucleus. Post-translationalmodification:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin.
MolecularWeight	~11kDa

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Millipore/05-1232 | Anti-acetyl Histone H4 (Lys16) Antibody, clone 4E10.2/05-1232/100 µg

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