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Millipore/05-1243 | Anti-Sirt1 Antibody, clone 3H10.2/05-1243/100 µg

價格: ￥5052.00 市場價: 8420.00

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貨號: 05-1243

品牌: Millipore

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Description
CatalogueNumber	05-1243
Replaces	05-707
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-Sirt1Antibody,clone3H10.2
BackgroundInformation	TheSir2proteininyeastisknowntofunctionintranscriptionalsilencingprocessesthroughthedeacetylationofhistonesH3andH4.ThemorerecentlydescribedhumanhomologueofSir2,knownasSIRT1,hasbeenfoundtoassociatewiththetumorsuppressorproteinp53.TherearenowfivedescribedhumanhomologsofyeastSir2,whicharenamedSIRT1-5. SIRT1bindsanddeacetylatesp53withspecificityforitsC-terminalLys382residueinresponsetotheupregulationofpromyelocyticleukemiaprotein(PML)nuclearbodiesoroncogenicRas.Thedeacetylationofp53SIRT1hasbeenshowntonegativelyregulatep53-mediatedtranscription,preventingcellularsenescenceandapoptosisinducedbyDNAdamageandstress.SIRT1isaHDACwhichisimportantinestablishingrepressivechromatinstructuresandplaysaroleinincreasingLifespan.

ProductInformation
Format	Purified
Presentation	PurifiedinPBSwith0.05%SodiumAzide

StorageandShippingInformation
StorageConditions	Maintainat2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.

Applications
Application	Anti-Sirt1Antibody,clone3H10.2isaMouseMonoclonalAntibodyfordetectionofSirt1alsoknownasSirtuin1,SilentmatingtypeInformationRegulation-2&hasbeentestedinIP&WB.
KeyApplications	Immunoprecipitation WesternBlotting

BIOLOGicalInformation
Immunogen	GSTfusionproteincorrespondingtoaminoacids508-616ofhumanSirt1.
Clone	3H10.2
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	HumanSirt1.DoesnotcrossreactwithlysatesfrommouseNIH/3T3cellsorratPC12cells.
Isotype	IgG1
SpeciesReactivity	Human
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_012238
EntrezGeneSummary	Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.
GeneSymbol	SIRT1 SIR2L1 hSIR2 OTTHUMP00000060745 hSIRT1 SIR2alpha
PurificationMethod	ProteinGPurified
UniProtNumber	Q96EB6
UniProtSummary	FUNCTION:SwissProt:Q96EB6#NAD-dependentdeacetylase,whichregulatesprocessessuchasapoptosisandmuscledifferentiationbydeacetylatingkeyproteins.Deacetylates"Lys-382"ofp53/TP53andimpairsitsABIlitytoinduceproapoptoticprogramandmodulatecellsenescence.DeacetylatesTAF1BandtherebyrepressesrDNAtranscriptionbytheRNApolymeraseI.InvolvedinHES1-andHEY2-mediatedtranscriptionalrepression.InhibitsskeletalmuscledifferentiationbydeacetylatingPCAFandMYOD1.MayserveasasensorofthecytosolicratioofNAD(+)/NADH,whichisessentialinskeletalmusclecelldifferentiation.Despitesomeabilitytodeacetylatehistonesinvitro,suchactivityiseitherweakorinexistentinvivo.IncaseofHIV-1infection,interactswithanddeacetylatestheviralTatprotein. COFACTOR:Binds1zincionpersubunit(Bysimilarity). SIZE:747aminoacids;81681Da SUBUNIT:InteractswithTAF1B.FoundinacomplexwithPCAFandMYOD1(Bysimilarity).InteractswithMLLT7/FOXO4,HES1,HEY2,p53/TP53andPML. SUBCELLULARLOCATION:Nucleus.Note=RecruitedtothenuclearbodiesviaitsinteractionwithPML.TISSUESPECIFICITY:Widelyexpressed. SIMILARITY:SwissProt:Q96EB6##Belongstothesirtuinfamily.&Contains1deacetylasesirtuin-typedomain. MISCELLANEOUS:Redwine,whichcontainsresveratrol,mayparticipateinactivationofsirtuinproteins,andmaythereforeparticipateinanextendedlifespanasithasbeenobservedinyeast.
MolecularWeight	120kDa

PhysicochemicalInformation

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Millipore/05-1243 | Anti-Sirt1 Antibody, clone 3H10.2/05-1243/100 µg

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