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Millipore/05-1312 | Anti-Ubiquityl-Histone H2B Antibody, clone 56/05-1312/100 µg

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貨號: 05-1312

品牌: Millipore

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Description
CatalogueNumber	05-1312
TradeName	Upstate
Description	Anti-Ubiquityl-HistoneH2BAntibody,clone56
AlternateNames	H2BUb HistoneH2B(ubiquityl) HIST1H2B H2BUbK119 H2BK119Ub
BackgroundInformation	HistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.HistonemodificationsregulateDNAtranscription,repair,recombination,andreplication.Themostcommonlystudiedmodificationsareacetylation,phosphorylation,methylation,andubiquitination.Thesemodificationscanalterlocalchromatinarchitecture,orrecruittrans-actingfactorsthatrecognizespecifichistonemodifications(the"histonecode"hypothesis).AnumberofstudieshaveimplicatedubiquitinatedH2Binheterochromaticgenesilencingandinthecontrolofgeneexpressionofseveralyeastgenes.

ProductInformation
Format	Purified
Control	HeLacelllysate.
Presentation	PurifiedfromascitesbyproteinGchromatography.Suppliedat1mg/mlin0.1MTris-Glycine(pH7.4)150mMNaCl,0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt. Formaximumrecoveryofproduct,centrifugethevialpriortoremovingthecap.

Applications
Application	Anti-Ubiquityl-HistoneH2BAntibody,clone56isaMouseMonoclonalAntibodyfordetectionofUbiquityl-HistoneH2BalsoknownasH2BUb,HistoneH2B(ubiquityl),HIST1H2B&hasbeenvalidatedinWB.
KeyApplications	WesternBlotting ChromatinImmunoprecipitation(ChIP)

BIOLOGicalInformation
Immunogen	ImmunogenusedwasabranchedpeptidecorrespondingtotheubiquitinationsiteonhumanH2B.
Epitope	UbiquitylLys120
Clone	clone56
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	RecognizeshistoneH2BwhenitisubiquitinatedatLys120butnotH2Binitsunmodifiedstate,orubiquitinunconjugatedtoH2B.Mr~25kDa.
Isotype	IgG2aκ
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Basedonsequencehomology,broadspeciescross-reactivityisexpected.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_066406.1
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.
Modifications	Ubiquitylation
PurificationMethod	ProteinGPurified
UniProtNumber	P62807
UniProtSummary	FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. Hasbroadantibacterialactivity.Maycontributetotheformationofthefunctionalantimicrobialbarrierofthecolonicepithelium,andtothebactericidalactivityofamnioticfluid. Subunitstructure:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. Subcellularlocation:Nucleus. Post-translationalmodification:MonoubiquitinationofLys-120bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.
MolecularWeight	~25kDa

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Millipore/05-1312 | Anti-Ubiquityl-Histone H2B Antibody, clone 56/05-1312/100 µg

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