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Millipore/05-1352 | Anti-Histone H2B Antibody, clone 5HH2-2A8/05-1352/100 µL

價格: ￥4680.00 市場價: 7800.00

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貨號: 05-1352

品牌: Millipore

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Description
CatalogueNumber	05-1352
Replaces	MABE15
Description	Anti-HistoneH2BAntibody,clone5HH2-2A8
AlternateNames	H2B HistoneH2B histone2,H2be histonecluster2,H2be H2Bhistonefamily,memberQ
BackgroundInformation	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofchromatinineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichDNAiswrappedinrepeatingunits,callednucleosomes.HistoneH2Bisoneofthemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH2Bisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.

ProductInformation
Format	Ascites
Control	HepG2celllysate,L6celllysate,MouseBrainLysate
Presentation	MousemonoclonalIgG1κasciteswith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	Anti-HistoneH2BAntibody,clone5HH2-2A8isaMouseMonoclonalAntibodyfordetectionofHistoneH2BalsoknownasHistoneH2B,histone2H2be&hasbeenvalidatedinWB,ICC.
KeyApplications	WesternBlotting Immunocytochemistry
ApplicationNotes	Immunocytochemistry: A1:500dilutionofarepresentativelotofthisantibodydetectedHistoneH2BinA431,HeLaandNIH/3T3cells.

BIOLOGicalInformation
Immunogen	Ovalbumin-conjugatedsyntheticlinearpeptidecorrespondingtotheC-terminusofHistoneH2B.
Epitope	C-terminus
Clone	clone5HH2-2A8
Host	Mouse
Specificity	AntibodyrecognizesHistoneH2BneartheC-terminus.
Isotype	IgG1κ
SpeciesReactivity	Mouse Human Rat
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	BC067487
EntrezGeneSummary	Histonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthesmallhistonegeneclusteronchromosome6p22-p21.3.[providedbyRefSeq]
GeneSymbol	H2B GL105 H2B-GL105 H2B.1 H2B.q H2B/q H2BFQ
PurificationMethod	Unpurified
UniProtNumber	Q99879
UniProtSummary	FUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:126aminoacids;13908Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination. SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
MolecularWeight	~15kDa

PhysicochemicalInformation

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Millipore/05-1352 | Anti-Histone H2B Antibody, clone 5HH2-2A8/05-1352/100 µL

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