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Millipore/05-1355 | Anti-acetyl Histone H4 (Lys5/8/12/16) Antibody, clone 3HH4-4C10/05-1355/100 µL

價格: ￥4680.00 市場價: 7800.00

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貨號: 05-1355

品牌: Millipore

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Description
CatalogueNumber	05-1355
Description	Anti-acetylHistoneH4(Lys5/8/12/16)Antibody,clone3HH4-4C10
AlternateNames	H4KAc HistoneH4(acetyl) H4histonefamily,memberN H4histone,family2 histone2,H4 histone2,H4a histoneIV,family2 histonecluster2,H4a
BackgroundInformation	HistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.AcetylationofhistoneH4occursatseveraldifferentlysinepositionsinthehistonetailandisperformedbyafamilyofenzymesknownasHistoneAcetylTransferases(HATs).PosttranslationalacetylationoftheconservedcorehistoneN-terminaltaildomainsistypicallyassociatedwithgeneactivation.

ProductInformation
Format	Ascites
Control	HeLaacidextractlysate
Presentation	UnpurifiedmousemonoclonalIgG1κpreservative-freeascites.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	UseAnti-acetylHistoneH4(Lys5/8/12/16)Antibody,clone3HH4-4C10(mousemonoclonalantibody)validatedinWB,ICCtodetectacetylHistoneH4(Lys5/8/12/16)alsoknownasH4KAc,HistoneH4(acetyl).
KeyApplications	WesternBlotting Immunocytochemistry
ApplicationNotes	ImmunocytochemistryAnalysis: 1:500dilutionfromarepresentativelotdetectedHistoneH4inA431andHeLacells.

BIOLOGicalInformation
Immunogen	LinearpeptidecorrespondingtohumanHistoneH4acetylatedatLys5/8/12/16.
Epitope	Lys5/8/12/16
Clone	3HH4-4C10
Host	Mouse
Specificity	ThisantibodyrecognizesHistoneH4.
Isotype	IgG1κ
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Demonstratedtoreactwithhuman.Predictedtoreactwithmouseandratbasedon100%sequencehomology.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_778224
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
GeneSymbol	HIST1H4A H4/J HIST1H4F HIST1H4L H4FN H4FA H4FH HIST1H4H H4F2 H4FM H4/A H4FK H4FG HIST2H4 H4FB H4/K HIST1H4I H4/N HIST1H4B H4FE H4/M H4/a HIST1H4E HIST4H4 HIST2H4A H4FC H4FI H4/H HIST1H4C H4/G HIST1H4K H4FJ H4FD H4/I H4/B H4/D H4/C HIST1H4J HIST1H4D H4/E
PurificationMethod	Unpurified
UniProtNumber	P62805
UniProtSummary	FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:103aminoacids;11367Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. SIMILARITY:BelongstothehistoneH4family.
MolecularWeight	~13kDa

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Millipore/05-1355 | Anti-acetyl Histone H4 (Lys5/8/12/16) Antibody, clone 3HH4-4C10/05-1355/100 µL

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