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Millipore/05-157 | Anti-MAP Kinase 2/Erk2 Antibody, clone 1B3B9/05-157/200 µg

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貨號: 05-157

品牌: Millipore

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Description
CatalogueNumber	05-157
Replaces	04-349
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-MAPKinase2/Erk2Antibody,clone1B3B9
AlternateNames	Extracellularsignal-regulatedkinase2 MAPkinase2 MAPK2 Mitogen-activatedproteinkinase2 extracellularsignal-regulatedkinase-2 mitogen-activatedproteinkinase1 proteintyrosinekinaseERK2.
BackgroundInformation	ERK2isactivatedbyMEK2,whichphosphorylatesneighboringthreonine183andtyrosine185residues.ERK2isaserine/threoninekinasethatphosphorylatesMAP2andmyelinbasicprotein.ThiskinaseisanimportantproximalcomponentoftheMAPkinasepathwayinvolvedintranseittingthesignalsfromgrowthfactors,neurotransmittersandhormonesatthecellsurfacetothetranscriptionaleventsinthenucleus.

ProductInformation
Format	Purified
Control	A431,HeLaandNIH/3T3celllysates IncludedPositiveAntigenControl:Catalog#12-301,non-stimulatedA431celllysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
Presentation	PurifiedmousemonoclonalIgG2ainbuffercontainingPBSwith0.05%sodiumazide.Storefrozenat-20°C,avoidfreezethawcycles.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations: Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	Anti-MAPKinase2/Erk2Antibody,clone1B3B9isanantibodyagainstMAPKinase2/Erk2foruseinIP&WB.
KeyApplications	Immunoprecipitation WesternBlotting
ApplicationNotes	Immunoprecipitation: 4μgofapreviouslotimmunoprecipitatedMAPKinase2/Erk2fromaRIPAlysatefrommouse3T3cells.Boilthecelllysateandletcoolbeforeaddingtheantibody,asthisantibodyonlybindstodenaturedMAPKinase.

BIOLOGicalInformation
Immunogen	HPLCpurifiedmurinerecombinantMAPKinase.Clone1B3B9
Clone	1B3B9
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	ThisantibodyrecognizesMAPkinaseencodedbythemapkgene,Mr42kDa.
Isotype	IgG2a
SpeciesReactivity	Avian Human Mouse Rat
SpeciesReactivityNote	ProventoreactwithHuman,Mouse,andRat. Otherspeciescrossreactivityisunknown.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_002745
EntrezGeneSummary	TheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol	MAPK1 p38 ERK P42MAPK ERK2 p40 PRKM1 p41mapk PRKM2 MAPK2 p42-MAPK p41 ERK-2 ERT1
PurificationMethod	ProteinGChromatography
UniProtNumber	P28482
UniProtSummary	FUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4). COFACTOR:Magnesium(Bysimilarity). SIZE:360aminoacids;41390Da SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4. DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases. PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme. SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain
MolecularWeight	42kDa

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Millipore/05-157 | Anti-MAP Kinase 2/Erk2 Antibody, clone 1B3B9/05-157/200 µg

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