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Millipore/05-412 | Anti-GSK3 Antibody, clone 4G-1E/05-412/100 µg

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貨號: 05-412

品牌: Millipore

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Description
CatalogueNumber	05-412
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-GSK3Antibody,clone4G-1E
AlternateNames	GSK-3alpha glycogensynthasekinase3alpha
BackgroundInformation	Glycogensynthasekinase-3(GSK-3),amultifunctionalserine/threoninekinase,isakeyregulatorofnumeroussignalingpathways.TwoisoformsofGSK-3arereportedinmammals:a51kDaGSK-3aanda47kDaGSK-3b.Thesetwoisoformsexhibitabout98%homologyintheirkinasedomains,butshareonlyabout36%identityinthelast76C-terminalaminoacidresidues.GSK-3acontainsaglycine-richextensionatitsN-terminus.Aminor(~15%oftotal)splicevariantofGSK-3b,GSK-3b2,hasalsobeenidentified,whichcontainsa13-residueinsertwithinthekinasedomain.Itexhibitsreducedkinaseactivitytowardstauproteincomparedwith‘unspliced’GSK-3b.GSK-3b2islocalizedprimarilytoneuronalcellbodies,unlikeunsplicedGSK-3bthatisalsofoundinneuronalprocesses.GSK-3bplaysakeyinhibitoryroleintheWntsignalingpathway.Wntgenesencodealargefamilyofsecreted,cysteine-richproteinsthatareimportantindevelopmentandinmaintenanceofadulttissues.AbnormalitiesinWntsignalingarereportedtopromotebothhumandgenerativediseasesandcancer.

ProductInformation
Format	Purified
Control	Jurkatecelllysate,293Tcellextract,rabbitspleenfibroblasts IncludedPositiveAntigenControl: Catalog#12-303,Jurkatlysate.Add2.5μLof2-mercaptoethanolper100μLoflysateandboilfor5minutestoreducethepreparation.Use20μgperlaneforminigels.
Presentation	ProteinGpurifiedmouseIgG1instoragebuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,and0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	Anti-GSK3Antibody,clone4G-1EdetectslevelofGSK3&hasbeenpublished&validatedforuseinIC&WB.
KeyApplications	Immunocytochemistry WesternBlotting
ApplicationsNotRecommended	Immunoprecipitation
ApplicationNotes	Immunoprecipitation: Notrecommended. Immunocytochemistry: 10μg/mLofapreviouslotshowedpositiveimmunostainingforGSK3inL6cellsfixedwithacetone.

BIOLOGicalInformation
Immunogen	18residuesyntheticpeptide(C-KQLLHGEPNVSYICSRY)correspondingtoaminoacids203-219derivedfromaregionofthecatalyticdomain(betweensuBDomainVIIandVIII)oftheDrosophilaGSK3/shaggyenzyme,coupledtoovalbumin.Clone4G-1E.
Clone	4G-1E
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	GSK3,αandβisoforms
Isotype	IgG1
SpeciesReactivity	Vertebrates Mouse Rat Human Dictyostelium Yeast(S.pombe)
SpeciesReactivityNote	Mouse,rat,S.pombe,Dictyosteliumandhuman.Becauseoftheextremelyhighconservationofthisimmunogenamongtheknownenzymesofmanydifferentspecies,thisantibodyispredictedtocross-reactwithnearlyallspecieshomologues.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_057366
EntrezGeneSummary	Glycogensynthasekinase3-alpha(GSK3A;EC{2.7.1.37})isamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthase(seeGYS1,{138570})andtranscriptionfactors(e.g.,JUN,{165160}).ItalsoplaysaroleintheWNT({164820})andPI3K(seePIK3CG,{601232})signalingpathways(seereviewby{1:Alietal.(2001)}).[suppliedbyOMIM]
GeneSymbol	GSK3A DKFZp686D0638
PurificationMethod	ProteinGPurified
UniProtNumber	P49840
UniProtSummary	FUNCTION:SwissProt:P49840#Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN(Bysimilarity). SIZE:483aminoacids;50981Da SUBUNIT:Monomer(Bysimilarity). SIMILARITY:SwissProt:P49840##Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.GSK-3subfamily.&Contains1protein
MolecularWeight	51kDa(α)or46kDa(β)

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Millipore/05-412 | Anti-GSK3 Antibody, clone 4G-1E/05-412/100 µg

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