當前位置： Millipore >>> Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg

Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg

價格: ￥3696.00 市場價: 6160.00

打印產品信息

貨號: 05-443

品牌: Millipore

規格

默認

數量

庫存(0)

特別提示

代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯系客服核對商品價格，訂單生效后再付款。

立即購買加入購物車

收藏商品

資深產品顧問

咨詢顧問

全國免費服務熱線

4000-520-616

自營商城一站式服務
廠家直采剔除溢價
品質甄選正品保證
嚴控流程只做188精品
極速物流如約送貨

詳情
使用說明
常見問題

Description
CatalogueNumber	05-443
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-VEGFAntibody,cloneJH
AlternateNames	VascularpermeABIlityfactor vascularendothelialgrowthfactor vascularendothelialgrowthfactorA vascularendothelialgrowthfactorisoformVEGF165
BackgroundInformation	TheFltgenefamilyofreceptortyrosinekinasesincludesFlt-1,KDR/Flk-1,Flt-3,andFlt-4.TheyencodereceptorsforVEGF,characterizedbysevenIg-loopswithintheirextracellulardomainandasplitkinasedomainwithinthecytoplasmicdomain.VEGFisanimportantangiogenicfactorofmanysolidtumorsandisalsoinvolvedinthedifferentiationofendothelialcells.Flt-1(Fms-liketyrosinekinase,VEGF-R1)isexpressedonendothelialcellsandonthecommonprecursorsofendothelialandhematopoieticstemcells.KDR(Flk-1,VEGF-R2)istheprincipalreceptorinvolvedinVEGFsignaling.KDRisexpressedonendothelialcellsandstimulatesangiogenesis,butisalsoexpressedonbonemarrowcells,andisthoughttoplayaroleindrivingtheproliferationofmostorallleukemiccells.Flt3isaclassIIIreceptortyrosinekinasethatiscloselyrelatedtoc-Kitandc-Fms.Itisexpressedinprimitivehematopoieticcellsanditsligandexertsproliferativeeffectsonthesecellsinco-operationwithothercytokines.Flt3isalsoexpressedtheplacenta,testis,spleen,thymus,bonemarrow,brainandincerebellarPurkinjecells.TheVEGFreceptorsstimulatetheRas-MAPkinasepathway,suggestingthatitsignalsasaconventionalreceptortyrosinekinase.

ProductInformation
Format	Purified
Control	Expressedinmosttissue,includingPancreas,Kidney,Adenocarcinoma.
Presentation	PurifiedmousemonoclonalIgG1kinbuffercontaining10mMPBS,pH7.4.

StorageandShippingInformation
StorageConditions	Stablefor1yearatfromdateofreceipt.

Applications
Application	ThisAnti-VEGFAntibody,cloneJHisvalidatedforuseinIH(P)forthedetectionofVEGF.
KeyApplications	Immunohistochemistry(Paraffin)
ApplicationsNotRecommended	WesternBlotting
ApplicationNotes	Immunohistochemistry:ThislotofantibodydetectedVEGFinformalinfixed,paraffinembedded,human.tissues,usinga1:50dilutionincubatedovernightat4°C. Immunoprecipitation:2μgofthisantibodyhasbeenreportedtoimmunoprecipitateVEGFfrom1mgofproteinlysate.

BIOLOGicalInformation
Immunogen	RecombinanthumanVEGF121.CloneJH121
Clone	cloneJH
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	Recognizes34-54kDaisoformsofVascularEndothelialGrowthFactor/VascularPermeabilityFactor(VEGF/VPF).
Isotype	IgG1κ
SpeciesReactivity	Human Mouse Rat Rabbit
SpeciesReactivityNote	Human,rabbit,mouse,andrat.Otherspeciesnottested.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_003376
EntrezGeneSummary	ThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.
GeneSymbol	VEGFA VEGF-A VEGF VPF MGC70609
PurificationMethod	ProteinGChromatography
UniProtNumber	P15692
UniProtSummary	FUNCTION:SwissProt:P15692#Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145. SIZE:232aminoacids;27042Da SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity). SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin. TISSUESPECIFICITY:TheVEGF189,VEGF-165andVEGF-121isoformsarewidelyexpressed,whereastheVEGF206andVEGF-145areuncommon. SIMILARITY:SwissProt:P15692##BelongstothePDGF/VEGFgrowthfactorfamily.
MolecularWeight	34-54kDaisoforms

PhysicochemicalInformation

Dimensions

MaterialsInformation

MaterialsInformation

售后保障

螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。

Q：生物188產品正品保障嗎？
A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購，自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

Q：下單后可以修改訂單嗎？
A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

Q：可以開發票嗎？
A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

Q：商品幾天可以發貨？
A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

Q：如何聯系商家？
A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

Q：收到的商品少了/發錯了怎么辦？
A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

Q：退換貨/維修需要多長時間？
A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

24小時熱銷榜

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
￥830.00
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
￥830.00
Qubit? dsDNA BR Assay Kit Q32853現貨
￥2000.00
Parafilm M封口膜/PM996/4x125/整箱
￥1296.00

Millipore/05-443 | Anti-VEGF Antibody, clone JH/05-443/100 µg

客戶服務

何為188

關注188微信公眾號