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Millipore/05-457 | Anti-Histone H1 Antibody, clone AE-4/05-457/200 µg

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貨號: 05-457

品牌: Millipore

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Description
CatalogueNumber	05-457
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-HistoneH1Antibody,cloneAE-4
AlternateNames	H1histonefamily,member4 HistoneH1b histone1 H1e histonecluster1 H1e
BackgroundInformation	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.

ProductInformation
Format	Purified
Control	NuclearextractsfromNIH3T3orHeLacells.
Presentation	PurifiedmousemonoclonalIgG2ainbuffercontainingPBS,pH7.2,with0.1%sodiumazide.Frozensolution.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations: Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	UseAnti-HistoneH1Antibody,cloneAE-4(mousemonoclonalantibody)validatedinELISA,ICC,WBtodetectHistoneH1alsoknownasH1histonefamilymember4,HistoneH1b,histone1H1e,histonecluster1H1e.
KeyApplications	ELISA Immunocytochemistry WesternBlotting
ApplicationNotes	Immunocytochemistry: 5-20μg/mLofapreviouslotshowedpositivenuclearimmunostaininginA431cellsfixedwith4%paraformaldehydeandmethanol. ELISA: Recommended.

BIOLOGicalInformation
Immunogen	Nucleifrommyeloidleukemiabiopsycells.CloneAE-4.
Clone	AE-4
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	ThisantibodyrecognizeshistoneH1,Mr32-33kDa.DoubletdetectedduetohyperphosphorylationofhistoneH1subpopulation.Cross-reactswithotherhistoneisoformsinthefollowingorderofsignalstrength:H3,H2B>H4>H2A,asdeterminedwithrecombinantprotein.
Isotype	IgG2a
SpeciesReactivity	Human Bovine GreenPlants
SpeciesReactivityNote	Humanandbovine.Predictedtostainnucleifromotheranimalandplantspecies.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_005322
EntrezGeneSummary	Histonesarebasicnuclearproteinsresponsiblefornucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH1family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
GeneSymbol	HIST1H1E H1F4 H1.4 dJ221C16.5 MGC116819
PurificationMethod	ProteinGPurified
UniProtNumber	P10412
UniProtSummary	FUNCTION:SwissProt:P10412#HistonesH1arenecessaryforthecondensationofnucleosomechainsintohigherorderstructures. SIZE:219aminoacids;21865Da SUBCELLULARLOCATION:Nucleus. SIMILARITY:SwissProt:P10412##BelongstothehistoneH1/H5family. MISCELLANEOUS:Thisvariantaccountsfor60%ofhistoneH1.
MolecularWeight	32-33kDa(HistoneH1);Doublet(hyperphosphorylatedHistoneH1);17kDa(otherhistoneisoforms).

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Millipore/05-457 | Anti-Histone H1 Antibody, clone AE-4/05-457/200 µg

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