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Millipore/05-636-KC | Anti-Phos-Hist H2A.1 (S139) (KC)/05-636-KC/Bulk packaging. Please inquire.

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貨號: 05-636-KC

品牌: Millipore

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Description
CatalogueNumber	05-636-KC
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-Phos-HistH2A.1(S139)(KC)
Overview	ThisproductisintendedforusebyIVDmanufacturers. Contactcustomerserviceforassistance:oem.reagents@emdMillipore.com
AlternateNames	H2AXS139P HistoneH2A.X(phosphoS139)
BackgroundInformation	HistoneH2Aisoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH2Aisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.

ProductInformation
Format	Purified
Control	UV-treated293cellextracts,UV-treatedHeLacellextractsorbreastcancertissue
Presentation	ImmunoaffinityPurifiedimmunoglobulinin0.1MTris-Glycine,pH7.4,0.15MNaCl,0.05%sodiumazideasapreservative.

StorageandShippingInformation
StorageConditions	Maintainfor1yearat2to8°Cfromdateofshipment.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap.

Applications
Application	Anti-phospho-HistoneH2A.X(Ser139),cloneJBW301isawellpublishedMouseMonoclonalAntibodyvalidatedinChIP,ICC,IF,WB.ThispurifiedmAbishighlyspecificforphospho-HistoneH2A.X(Ser139)alsoknownasH2AXS139p.
KeyApplications	Immunocytochemistry Immunofluorescence WesternBlotting ChromatinImmunoprecipitation(ChIP)
ApplicationNotes	AdditionalReferencedApplications: ChromatinImmunoprecipitation,seeMeier,Andreas,etal.EMBOJ.,26:2707-18(2007)intechnicalinformationtab.

BIOLOGicalInformation
Immunogen	peptide(C-KATQA[pS]QEY)correspondingtoaminoacids134-142ofhumanhistoneH2A.X
Clone	JBW301
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	RecognizesHistoneH2A.XphosphorylatedatSer139.
Isotype	IgG1
SpeciesReactivity	Vertebrates
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP002096
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
GeneSymbol	H2AFX H2AX H2a/x H2A/X H2A.X
Modifications	Phosphorylation
PurificationMethod	ProteinGPurified
UniProtNumber	P16104
UniProtSummary	FUNCTION:SwissProt:P16104#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation. SIZE:143aminoacids;15145Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140. SUBCELLULARLOCATION:Nucleus.DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase. DOMAIN:SwissProt:P16104The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily. PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity). SIMILARITY:BelongstothehistoneH2Afamily.
MolecularWeight	17kDa

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