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Millipore/05-736 | Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal/05-736/100 µg

價格: ￥3576.00 市場價: 5960.00

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貨號: 05-736

品牌: Millipore

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Description
CatalogueNumber	05-736
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-phospho-Akt1/PKBα(Ser473)Antibody,cloneSK703,rabbitmonoclonal

ProductInformation
Format	Purified
Presentation	ProteinApurifiedantibodyin0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablerefrigeratedat2-8°Cinundilutedaliquotsforupto1yearfromdateofreceipt.

Applications
Application	Detectphospho-Akt1/PKBα(Ser473)usingthisAnti-Akt1Antibody,cloneSK703validatedforuseinWB.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	PeptidecontainingapSerthatcorrespondstoaminoacidposition473ofhumanAkt1/PKBa
Clone	SK703
Host	Rabbit
Specificity	phosphorylatedAkt1/PKBa
Isotype	IgG
SpeciesReactivity	Human Mouse
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_005163
EntrezGeneSummary	Theserine-threonineproteinkinaseencodedbytheAKT1geneiscatalyticallyinactiveinserum-starvedprimaryandimmortalizedfibroblasts.AKT1andtherelatedAKT2areactivatedbyplatelet-derivedgrowthfactor.Theactivationisrapidandspecific,anditisabrogatedbymutationsinthepleckstrinhomologydomainofAKT1.Itwasshownthattheactivationoccursthroughphosphatidylinositol3-kinase.InthedevelopingnervoussystemAKTisacriticalmediatorofgrowthfactor-inducedneuronalsurvival.Survivalfactorscansuppressapoptosisinatranscription-independentmannerbyactivatingtheserine/threoninekinaseAKT1,whichthenphosphorylatesandinactivatescomponentsoftheapoptoticmachinery.Multiplealternativelysplicedtranscriptvariantshavebeenfoundforthisgene.
GeneSymbol	AKT1 RAC PRKBA RAC-ALPHA PKB MGC99656 RAC-PK-alpha C-AKT AKT
Modifications	Phosphorylation
PurificationMethod	ProteinAPurfied
UniProtNumber	P31749
UniProtSummary	FUNCTION:SwissProt:P31749#Generalproteinkinasecapableofphosphorylatingseveralknownproteins.PhosphorylatesTBC1D4.Signalsdownstreamofphosphatidylinositol3-kinase(PI(3)K)tomediatetheeffectsofvariousgrowthfactorssuchasplatelet-derivedgrowthfactor(PDGF),epidermalgrowthfactor(EGF),insulinandinsulin-likegrowthfactorI(IGF-I).Playsaroleinglucosetransportbymediatinginsulin-inducedtranslocationoftheGLUT4glucosetransportertothecellsurface.MediatestheantiapoptoticeffectsofIGF-I.Mediatesinsulin-stimulatedproteinsynthesis,partlybyplayingaroleinbothinsulin-inducedphosphorylationof4E-BP1andininsulin-inducedactivationofp70S6kinase.Promotesglycogensynthesisbymediatingtheinsulin-inducedactivationofglycogensynthase. SIZE:480aminoacids;55686Da SUBUNIT:InteractswithCENTG1isoform2(PIKE-A)inthepresenceofguaninenucleotides.TheC-terminusinteractswithCCDC88A/GRDN.InteractswithAKTIP. SUBCELLULARLOCATION:Cytoplasm.Nucleus.Note=Nucleusafteractivationbyintegrin-linkedproteinkinase1(ILK1). TISSUESPECIFICITY:Inallhumancelltypessofaranalyzed. DOMAIN:SwissProt:P31749BindingofthePHdomaintothephosphatidylinositol3-kinasealpha(PI(3)K)resultsinitstargetingtotheplasmamembrane. PTM:PhosphorylationonThr-308,Ser-473andTyr-474isrequiredforfullactivity.Ser-473phosphorylationbytheRictor-mTorcomplexfavorsThr-308phosphorylationbyPDPK1.Ser-473phosphorylationisenhancedbyinteractionwithCENTG1isoform2(PIKE-A). SIMILARITY:Belongstotheproteinkinasesuperfamily.AGCSer/Thrproteinkinasefamily.RACsubfamily.&Contains1AGC-kinaseC-terminaldomain.&Contains1PHdomain.&Contains1proteinkinasedomain.
MolecularWeight	60kDa

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Millipore/05-736 | Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal/05-736/100 µg

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