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Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon

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貨號: 05-797R

品牌: Millipore

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Description
CatalogueNumber	05-797R
Replaces	05-797
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-phospho-Erk1/2(Thr202/Tyr204,Thr185/Tyr187)Antibody,recombinantcloneAW39R,rabbitmonoclonal
AlternateNames	Erk1 Erk2 p44-MAPK p42-MAPK MAPK2 PRKM2 p41mapk PRKM1 p44 ERK2 P42MAPK ERK p42 MAPK1 ERT1 ERT2 Mitogen-activatedproteinkinase MAPKinase2 MAPKianse1 MAPK
BackgroundInformation	Erk(Extracellularsignal-RelatedKinase)isafamilyoftwo,highlyhomologousproteinsdenotedasErk1(p44,MAPK3)andErk2(p42,MAPK1)thatbothfunctioninthesamepathway.ThetwoproteinsareoftenreferredtocollectivelyasErk1/2orp44/p42MAPkinase.TheErkpathwayisconsideredtheclassical,canonicalMAPK(Mitogen-ActivatedProteinKinase)signalingpathway.Itisanevolutionarilyconservedpathwaythatcontrolsandisacriticalregulatorofthegrowthandsurvivalthroughthepromotionofcellproliferationandthepreventionofapoptosis.Erkisinvolvedinthecontrolofmanyfundamentalcellularprocessesincludingcellproliferation,survival,differentiation,apoptosis,motilityandmetabolism.Erkisactivatedbygrowthfactorstimulationofreceptortyrosinekinases(RTKs),GPCR,and/orintegrinstimulation.ThisactivatestheRas-Raf-MEK-Erkpathwaythatresultsinthephosphorylation/activationofErk1/2(p44/p42)ontheTxYmotif(Thr202/Tyr204andThr185/Tyr187forErk1&Erk2,respectively).

ProductInformation
Format	Purified
Control	PDGF-treatedNIH/3T3celllysates
Presentation	ProteinAPurifiedimmunoglobulinin30%glycerol,0.07MTris-glycine,pH7.4,0.105MNaCl,0.035%sodiumazideasapreservative.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt.HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	Anti-phospho-Erk1/2(Thr202/Tyr204Antibody,Thr185/Tyr187),recombinantcloneAW39Rdetectslevelofphospho-Erk1/2(Thr202/Tyr204&hasbeenpublished&validatedforuseinMplex&WB.
KeyApplications	Multiplexing WesternBlotting

BIOLOGicalInformation
Immunogen	PhosphorylatedpeptidecorrespondingtoaminoacidssurroundingthepTEpYmotifintheactivationloopofhumanphospho-Erk1/2,inwhichtheThrandTyrresiduesarephosphorylated
Epitope	pTEpYintheactivationloop
Clone	AW39R
Host	Rabbit
Specificity	RecognizesErk1&2onlywhenduallyphosphorylatedonitsTxYactivationmotif.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_002736 NP_002737
EntrezGeneSummary	TheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actasanintegrationpointformultiplebiochemicalsignals,andareinvolvedinawidevarietyofcellularprocessessuchasproliferation,differentiation,transcriptionregulationanddevelopment.Theactivationofthiskinaserequiresitsphosphorylationbyupstreamkinases.Uponactivation,thiskinasetranslocatestothenucleusofthestimulatedcells,whereitphosphorylatesnucleartargets.Twoalternativelysplicedtranscriptvariantsencodingthesameprotein,butdifferingintheUTRs,havebeenreportedforthisgene.
GeneSymbol	Erk1 Erk2 p44-MAPK p42-MAPK MAPK2 PRKM2 p41mapk PRKM1 p44 ERK2 P42MAPK ERK p42 MAPK1 ERT1 ERT2 Mitogen-activatedproteinkinase MAPKinase2 MAPKianse1 MAPK
Modifications	Phosphorylation
PurificationMethod	ProteinAPurfied
UniProtNumber	P28482 P27361
UniProtSummary	FUNCTION:SwissProt:P28482#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4). COFACTOR:Magnesium(Bysimilarity). SIZE:360aminoacids;41390Da SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1NefthroughitsSH3domain.Thisinteractioninhibitsitstyrosine-kinaseactivity.InteractswithHSF4. DOMAIN:SwissProt:P28482TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases. PTM:DuallyphosphorylatedonThr-185andTyr-187,whichactivatestheenzyme. SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain.
MolecularWeight	Erk1(p44)(~44kDa)andErk2(p42)(~42kDa).

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Millipore/05-797R | Anti-phospho-Erk1/2 (Thr202/Tyr204, Thr185/Tyr187)Antibody, recombinant clone AW39R, rabbit monoclon

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