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Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg

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貨號: 05-814

品牌: Millipore

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Description
CatalogueNumber	05-814
Replaces	04-229
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-HDAC2Antibody,clone3F3
AlternateNames	YY1-associatedfactor1 histonedeacetylase2 transcriptionalregulatorhomologRPD3
BackgroundInformation	Histonedeacetylase2(HDAC2),ortranscriptionalregulatorhomologRPD3L1,ishighlyhomologoustotheyeasttranscriptionfactorRPD3(reducedpotassiumdependency3)gene.Asinyeast,humanHDA2islikelytobeinvolvedinregulatingchromatinstructureduringtranscription.IthasbeenimplicatedtoassociatewithYY1,amammalianzinc-fingertranscriptionfactor,whichnegativelyregulatestranscriptionbytetheringRPD3toDNAasacofactor.Thisprocessishighlyconservedfromyeasttohuman.

ProductInformation
Format	Purified
Control	IncludedPositiveAntigenControl:Catalog#12-309,HeLanuclearextract.AddanequalvolumeofLaemmlireducingsamplebufferto10μLofextractandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
Presentation	PurifiedmousemonoclonalIgGinbuffercontaining70%storagebuffer(0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazide)and30%glycerol.Storeat-20°C.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt.

Applications
Application	Anti-HDAC2Antibody,clone3F3isaMouseMonoclonalAntibodyfordetectionofHDAC2alsoknownasYY1-associatedfactor1,histonedeacetylase2&hasbeenvalidatedinICC,IP&WB.
KeyApplications	Immunocytochemistry Immunoprecipitation WesternBlotting
ApplicationNotes	Immunocytochemistry: ThisantibodyhasbeenreportedbyanindependentlaboratorytoshowpositiveimmunostainingforHDAC2inNIH/3T3andU2OScellsfixedwithparaformaldehyde. ImmunoprecipitationandHDACAssay: 3μLofapreviouslotwasusedtoimmunoprecipitateHDACactivityfromHeLanuclearextract,whichwasthenmeasuredusingtheHDACAssayKit(FluorometricDetection)(Catalog#17-356).Anindependentlaboratoryhasalsodemonstratedpositiveimmunoprecipitation/HDACassayresultsusingNIH/3T3cells.

BIOLOGicalInformation
Immunogen	KLH-conjugated,syntheticpeptide(CEKTDTKGTKSEQLSNP)correspondingtoaminoacids473-488ofhumanHDAC2(Accession#NP_001518)containingaN-terminalcysteine
Clone	3F3
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	RecognizesHDAC2,MW~60kDa.
Isotype	IgG1
SpeciesReactivity	Human Bovine Mouse Rat Hamster
SpeciesReactivityNote	Human,mouse,bovineandhamster.Predictedtocross-reactwithratbasedonsequencehomology.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_001518
EntrezGeneSummary	Thisgeneproductbelongstothehistonedeacetylasefamily.HistonedeacetylasesactviatheformationoflargemultiproteincomplexesandareresponsIBLeforthedeacetylationoflysineresiduesontheN-terminalregionofthecorehistones(H2A,H2B,H3andH4).Thisproteinalsoformstranscriptionalrepressorcomplexesbyassociatingwithmanydifferentproteins,includingYY1,amammalianzinc-fingertranscriptionfactor.Thusitplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.
GeneSymbol	HDAC2 HD2 YAF1 RPD3
PurificationMethod	ProteinGPurified
UniProtNumber	Q92769
UniProtSummary	FUNCTION:SwissProt:Q92769#FormstranscriptionalrepressorcomplexesbyassociatingwithMAD,SIN3,YY1andN-COR.InteractsinthelateS-phaseofDNA-replicationwithDNMT1intheothertranscriptionalrepressorcomplexcomposedofDNMT1,DMAP1,PCNA,CAF1. SIZE:488aminoacids;55364Da SUBUNIT:Interactswiththenon-histoneregionofH2AFY(Bysimilarity).Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.PartofacomplexcontainingthecorehistonesH2A,H2B,H3andH4,DEKandunphosphorylatedDAXX.PartofacomplexcontainingATRandCHD4.FormsaheterologouscomplexatleastwithYY1.InteractswithATR,DNMT1,MINT,HDAC7,HDAC10,HCFC1,NRIP1,MJD2A/JHDM3A,SAP30,SETDB1andSUV39H1.Interactswiththenon-histoneregionofH2AFY.InteractswithPELP1.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithCBFA2T3.InteractswithSAP30L. SUBCELLULARLOCATION:Nucleus.TISSUESPECIFICITY:Widelyexpressed;lowerlevelsinbrainandlung. SIMILARITY:SwissProt:Q92769##Belongstothehistonedeacetylasefamily.Type1subfamily.
MolecularWeight	~60kDa

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Millipore/05-814 | Anti-HDAC2 Antibody, clone 3F3/05-814/200 µg

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