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Millipore/05-858R | Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal/05-858R/100 µL

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貨號: 05-858R

品牌: Millipore

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Description
CatalogueNumber	05-858R
Description	Anti-HistoneH4Antibody,pan,clone62-10C-2,rabbitmonoclonal
AlternateNames	H4 HistoneH4 H4histonefamily,memberA histone1,H4a histonecluster1,H4a
BackgroundInformation	HistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.

ProductInformation
Format	Purified
Control	HeLaacidextract
Presentation	PurifiedRabbitMonoclonalIgGSupernatantinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl),containing40%glycerolwith0.05%sodiumazide

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt.

Applications
Application	UseAnti-HistoneH4Antibody,pan,clone62-10C-2(RabbitMonoclonalAntibody)validatedinWBtodetectHistoneH4alsoknownasHistoneH4.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids17-28ofHistoneH4.
Epitope	Epitopemappedtoresidues25-28.
Clone	62-10C-2
Host	Rabbit
Specificity	ThisantibodyrecognizeshistoneH4.
Isotype	IgG
SpeciesReactivity	Human
SpeciesReactivityNote	Demonstratedtoreactwithonhuman.Broadspeciescross-reactivityexpectedbasedon100%sequencehomologytomultiplespecies.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NP_003529
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.[providedbyRefSeq]
GeneSymbol	HIST1H4A H4/J HIST1H4F HIST1H4L H4FN H4FA H4FH HIST1H4H H4F2 H4FM H4/A H4FK H4FG HIST2H4 H4FB H4/K HIST1H4I H4/N HIST1H4B H4FE H4/M H4/a HIST1H4E HIST4H4 HIST2H4A H4FC H4FI H4/H HIST1H4C H4/G HIST1H4K H4FJ H4FD H4/I H4/B H4/D H4/C HIST1H4J HIST1H4D H4/E
PurificationMethod	ProteinAPurfied
UniProtNumber	P62805
UniProtSummary	FUNCTION:Swiss-ProtP62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:AcetylationatLys-6,Lys-9,Lys-13andLys-17occursincodingregionsofthegenomebutnotinheterochromatin. CitrullinationatArg-4byPADI4impairsmethylation. MonomethylationatArg-4byPRMT1favorsacetylationatLys-9andLys-13.DemethylationisperformedbyJMJD6. Monomethylated,dimethylatedortrimethylatedatLys-21.MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing. UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. Sumoylated,whichisassociatedwithtranscriptionalrepression. SEQUENCESIMILARITIES:BelongstothehistoneH4family.
MolecularWeight	10kDaObserved

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Millipore/05-858R | Anti-Histone H4 Antibody, pan, clone 62-10C-2, rabbit monoclonal/05-858R/100 µL

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