當前位置： Millipore >>> Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg

Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg

價格: ￥4680.00 市場價: 7800.00

打印產品信息

貨號: 06-720

品牌: Millipore

規格

默認

數量

庫存(0)

特別提示

代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯系客服核對商品價格，訂單生效后再付款。

立即購買加入購物車

收藏商品

資深產品顧問

咨詢顧問

全國免費服務熱線

4000-520-616

自營商城一站式服務
廠家直采剔除溢價
品質甄選正品保證
嚴控流程只做188精品
極速物流如約送貨

詳情
使用說明
常見問題

Description
CatalogueNumber	06-720
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-HDAC1Antibody
AlternateNames	histonedeacetylase1,reducedpotassiumdependency,yeasthomolog-like1
BackgroundInformation	MammalianHADC1(alsodesignatedHD1),HDAC2(alsodesignatedmammalianRPD3)andHDAC3,allarerelatedtotheyeasttranscriptionalregulatorRpd3p,areidentifiedashistonedeacetylases.Thedeacetylationofhistonesisassociatedwithtranscriptionalsilencing.

ProductInformation
Format	Purified
Control	NIH/3T3cellextract IncludedPositiveAntigenControl:Catalog#12-305,3T3/A31CellLysate.Add2.5μLof2-mercaptoethanolper100μLoflysateandboilfor5minutestoreducethepreparation.Load20μgofreducedlysateperlaneforminigels.
Presentation	PurifiedrabbitpolyclonalIgGinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaCl,containing0.05%sodiumazide.Frozenat-20oC.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. HandlingRecommendations: Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	UseAnti-HDAC1Antibody(RabbitPolyclonalAntibody)validatedinEA,ICC,IP,WBtodetectHDAC1alsoknownashistonedeacetylase1.
KeyApplications	EnzymeAssays Immunocytochemistry Immunoprecipitation WesternBlotting
ApplicationNotes	Immunoprecipitation: 5μgofapreviouslotimmunoprecipitatedHDAC1from500μgof3T3/A31RIPAlysate. Immunocytochemistry: ThisantibodyhasbeenreportedtoimmunostainHDAC1in1%paraformaldehydefixed,0.1%TritonX-100permeABIlized3T3cells. HDACActivity: ThisantibodyhasbeenreportedtoimmunoprecipitateactiveHDAC.

BIOLOGicalInformation
Immunogen	6X-His-taggedfragmentrepresentingaminoacids53-482ofmousehistonedeacetylase1(HDAC1).
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	RecognizesandisspecificforHDAC1,Mr65kDa.Maydetectsanon-specificproteinat~35kDa.
Isotype	IgG
SpeciesReactivity	Human Rat Mouse
SpeciesReactivityNote	Mouse,ratandhuman.Otherspeciescross-reactivitynottested.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_004955
EntrezGeneSummary	Histoneacetylationanddeacetylation,catalyzedbymultisubunitcomplexes,playakeyroleintheregulationofeukaryoticgeneexpression.Theproteinencodedbythisgenebelongstothehistonedeacetylase/acuc/aphafamilyandisacomponentofthehistonedeacetylasecomplex.Italsointeractswithretinoblastomatumor-suppressorproteinandthiscomplexisakeyelementinthecontrolofcellproliferationanddifferentiation.Togetherwithmetastasis-associatedprotein-2,itdeacetylatesp53andmodulatesitseffectoncellgrowthandapoptosis.[providedbyRefSeq]
GeneSymbol	HDAC1 DKFZp686H12203 HD1 RPD3L1 GON-10 RPD3
PurificationMethod	ProteinAchromatography
UniProtNumber	Q13547
UniProtSummary	FUNCTION:SwissProt:Q13547#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes. SIZE:482aminoacids;55103Da SUBUNIT:Partofthecorehistonedeacetylase(HDAC)complexcomposedofHDAC1,HDAC2,RBBP4andRBBP7.ThecorecomplexassociateswithMTA2,MBD2,MBD3,MTA1L1,CHD3andCHD4toformthenucleosomeremodelingandhistonedeacetylation(NuRD)complex,orwithSIN3,SAP18andSAP30toformtheSIN3HDACcomplex.ComponentofaBHChistonedeacetylasecomplexthatcontainsHDAC1,HDAC2,HMG20B/BRAF35,AOF2/LSD1,RCOR1/CoRESTandPHF21A/BHC80.TheBHCcomplexmayalsocontainZMYM2,ZNF217,ZMYM3,GSE1andGTF2I.Associateswiththe9-1-1complex;interactswithHUS1.FoundinacomplexwithDNMT3AandHDAC7.InteractswithBCOR,BRMS1L,DAXX,DNMT1,EP300,HCFC1,PCAF,PHB2,MIER1,JMJD2A/JHDM3A,MINT,NRIP1,RERE,SETDB1,SUV39H1,TGIF,TGIF2,UHRF1andUHRF2.Interactswiththenon-histoneregionofH2AFY.InteractswithHDAC9.ComponentofamSin3AcorepressorcomplexthatcontainsSIN3A,SAP130,SUDS3/SAP45,ARID4B/SAP180,HDAC1andHDAC2.InteractswithBANP,CBFA2T3andJARID1B.InteractswithSAP30L. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Ubiquitous,withhigherlevelsinheart,pancreasandtestis,andlowerlevelsinkidneyandbrain. PTM:SumoylatedonLys-444andLys-476;whichpromotesenzymaticactivity.DesumoylatedbySENP1.&PhosphorylationonSer-421andSer-423promotesenzymaticactivityandinteractionswithNuRDandSIN3complexes. SIMILARITY:SwissProt:Q13547##Belongstothehistonedeacetylasefamily.Type1subfamily.
MolecularWeight	65kDa

PhysicochemicalInformation

Dimensions

MaterialsInformation

MaterialsInformation

售后保障

螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。

Q：生物188產品正品保障嗎？
A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購，自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

Q：下單后可以修改訂單嗎？
A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

Q：可以開發票嗎？
A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

Q：商品幾天可以發貨？
A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

Q：如何聯系商家？
A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

Q：收到的商品少了/發錯了怎么辦？
A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

Q：退換貨/維修需要多長時間？
A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

24小時熱銷榜

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
￥830.00
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
￥830.00
Qubit? dsDNA BR Assay Kit Q32853現貨
￥2000.00
Parafilm M封口膜/PM996/4x125/整箱
￥1296.00

Millipore/06-720 | Anti-HDAC1 Antibody/06-720/200 µg

客戶服務

何為188

關注188微信公眾號