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Millipore/06-866 | Anti-acetyl-Histone H4 Antibody/06-866/200 µL

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貨號: 06-866

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Description
CatalogueNumber	06-866
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-acetyl-HistoneH4Antibody
AlternateNames	H4histonefamily,memberA histone1 H4a histonecluster1 H4a
BackgroundInformation	HistoneH4isoneofthe5mainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltailH4isinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.AcetylationofhistoneH4occursatseveraldifferentlysinepositionsinthehistonetailandisperformedbyafamilyofenzymesknownasHistoneAcetylTransferases(HATs).

ProductInformation
Format	Serum
Control	TSA-treatedJurkatcells.Foranegativecontrol,performano-antibodyimmunoprecipitationbyincubatingthesupernatantfractionwith60μlofSalmonSpermDNA/ProteinAAgarose-50%Slurry.TranscriptionallyunactivatedDNAsamplesshouldbepreparedascontrolsforPCR.
Presentation	Wholeantiserumcontaining0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20°Cfromdateofreceipt. Aliquottoavoidrepeatedfreezingandthawing.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.

Applications
Application	UseAnti-acetyl-HistoneH4Antibody(RabbitPolyclonalAntibody)hasbeenpublishedandvalidatedinChIP,WB,ICCtodetectacetyl-HistoneH4alsoknownasH4histonefamilymemberA,histone1-H4a.
KeyApplications	WesternBlotting Immunocytochemistry ChromatinImmunoprecipitation(ChIP)
ApplicationNotes	ChromatinImmunoprecipitation: 5-10μLofthislotimmunoprecipitatedtranscriptionallyactivechromatincontainingacetylatedhistoneH4from2X106serumstimulatedHeLacells.

BIOLOGicalInformation
Immunogen	KLH-conjugatedpeptidecorrespondingtoa.a.2-19ofTetrahymenahistoneH4[AGGAcKGGAcKGMGAcKVGAAcKRHS-C],acetylatedonlysines5,8,12and16.
Epitope	a.a.2-19
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	AcetylatedhistoneH4,acetylatedhistoneH2BfromTetrahymenaandweaklycross-reactswithacetylatedhistoneH2BfromHeLacells,maycross-reactwithotheracetylatedproteins.
Isotype	IgG
SpeciesReactivity	Human Tetrahymena Eukaryote
SpeciesReactivityNote	HumanandTetrahymena.Otherspeciesnottested,butexpectedtocross-reactsinceHistoneH4iswellconserved.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_175054
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtailsbutinsteadcontainapalindromicterminationelement.Thisgeneisfoundinthelargehistonegeneclusteronchromosome6.
GeneSymbol	HIST1H4A H4/J HIST1H4F HIST1H4L H4FN H4FA H4FH HIST1H4H H4F2 H4FM H4/A H4FK H4FG HIST2H4 H4FB H4/K HIST1H4I H4/N HIST1H4B H4FE H4/M H4/a IST1H4E HIST4H4 HIST2H4A H4FC H4FI H4/H HIST1H4C H4/G HIST1H4K 4FJ H4FD H4/I H4/B H4/D H4/C HIST1H4J HIST1H4D H4/E
Modifications	Acetylation
PurificationMethod	Unpurified
UniProtNumber	P62805
UniProtSummary	FUNCTION:SwissProt:P62805#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:103aminoacids;11367Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:SymmetricdimethylationonArg-4bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage(Bysimilarity).&UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirrADIation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins. SIMILARITY:SwissProt:P62805##BelongstothehistoneH4family.
MolecularWeight	10kDa

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Millipore/06-866 | Anti-acetyl-Histone H4 Antibody/06-866/200 µL

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