| Immunogen | KLH-conjugated,syntheticpeptidecorrespondingtoaminoacids129-137ofhumanHDAC4(C-EHQRKLERH) |
| Host | Rabbit |
| Specificity | HDAC4 |
| Isotype | IgG |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.TheproteinencodedbythisgenebelongstoclassIIofthehistonedeacetylase/acuc/aphafamily.Itpossesseshistonedeacetylaseactivityandrepressestranscriptionwhentetheredtoapromoter.ThisproteindoesnotbindDNAdirectly,butthroughtranscriptionfactorsMEF2CandMEF2D.ItseemstointeractinamultiproteincomplexwithRbAp48andHDAC3. |
| GeneSymbol | - HDAC4
- HD4
- HDAC-A
- KIAA0288
- HDACA
- HA6116
|
| PurificationMethod | ProteinAchromatography |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P56524#ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationviaitsinteractionwiththemyocyteenhancerfactorssuchasMEF2A,MEF2CandMEF2D.
SIZE:1084aminoacids;119070Da
SUBUNIT:InteractswithHDAC7(Bysimilarity).Homodimer.HomodimerizationviaitsN-terminaldomain.InteractswithMEF2CandNR2C1.Interactswitha14-3-3chaperoneproteininaphosphorylationdependentmanner.InteractswithBTBD14B(Bysimilarity).InteractswithJARID1B.
SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Shuttlesbetweenthenucleusandthecytoplasm.Uponmusclecellsdifferentiation,itaccumulatesinthenucleiofmyotubes,suggestingapositiveroleofnuclearHDAC4inmuscledifferentiation.Theexporttocytoplasmdependsontheinteractionwitha14-3-3chaperoneproteinandisduetoitsphosphorylationatSer-246,Ser-467andSer-632byCaMK4.Thenuclearlocalizationprobablydependsonsumoylation.
TISSUESPECIFICITY:Ubiquitous.
DOMAIN:SwissProt:P56524Thenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasm.
PTM:PhosphorylatedbyCaMK4atSer-246,Ser-467andSer-632.Phosphorylationatotherresiduesisrequiredfortheinteractionwith14-3-3.&SumoylationonLys-559ispromotedbytheE3SUMO-proteinligaseRANBP2,andpreventedbyphosphorylationbyCaMK4.
SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily. |
| MolecularWeight | 119kDa |
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