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Millipore/07-1413 | Anti-GSK-3b Antibody, a.a. 335-349/07-1413/50 µg

價格: ￥3696.00 市場價: 6160.00

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貨號: 07-1413

品牌: Millipore

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Description
CatalogueNumber	07-1413
Replaces	AB8687
Description	Anti-GSK-3bAntibody,a.a.335-349
BackgroundInformation	GSK3(GlycogenSynthaseKinase3)differsfrommostserine/threoninekinasesinthatitisactiveintheabsenceoftheactionofsignalingpathways.Twoisoformsexist,GSK3αandGSK3β.ThefunctionofGSK3istophosphorylateGlycogenSynthaseandtherebyinactivateit.InsulinactionstimulatesthePI3Kinasepathway,resultinginAktactivation,whichphosphorylatesandinactivatesGSK3.GlycogenSynthaseisthenrapidlydephosphorylatedandactivated.OtherGSK3substratesincludeJun(oninhibitorysites),andeIF2B.PhosphorylationofTaubyGSK3mayrelatetodevelopmentofAlzheimer"sdisease.Phosphorylationstate-specificantibodiesdirectedagainsttheAktsite(Ser21)onGSK3aresuitableforsurrogateassaysoftheactivationstateofthepathway.

ProductInformation
Format	AffinityPurified
Control	C2C12CellLysate,Helacells,ratormousebrain
Presentation	PurifiedpolyclonalIgGantibodyissuppliedinPBS,pH7.2,50%glyceroland0.09%sodiumazide.

StorageandShippingInformation
StorageConditions	Stableat–20oCforuptooneyearfromdateofreceipt.Productmaybestoredatfor2-4weeksat2o-8oC. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

StorageandShippingInformation

StorageConditions

Stableat–20oCforuptooneyearfromdateofreceipt.Productmaybestoredatfor2-4weeksat2o-8oC.
HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	ThisAntiI-GSK-3bAntibody,a.a.335-349isvalidatedforuseinWB,IP,IH(P)forthedetectionofAntiI-GSK-3b.
KeyApplications	WesternBlotting Immunoprecipitation Immunohistochemistry(Paraffin)
ApplicationNotes	Immunoprecipitation:12.5μg/mLdilutionofapreviouslotwasuedinimmunoprecipitationonratbraintissue;immunoprecipitationswithtissueextractsotherthanbrainmayrequirehigherantibodyconcentrations. Optimalworkingdilutionsmustbedeterminedbytheenduser. Immunohistochemistry(paraffin): Representativetestingfromapreviouslot. OptimalStainingofGSK3βPolyclonalAntibody:HeLaCells

BIOLOGicalInformation
Immunogen	RatGSK3betasyntheticpeptide(aa.335-349),conjugatedtoKLH.Thissequenceis100%identicaltohumanGSK3beta.
Epitope	a.a.335-349
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	Thisantibodydetectsastrong47kDaprotein,correspondingtotheexpectedmolecularmassofGSK3beta.
Isotype	IgG
SpeciesReactivity	Rat Human Mouse Bovine
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_002093
EntrezGeneSummary	Glycogensynthasekinase-3(GSK3)isaproline-directedserine-threoninekinasethatwasinitiallyidentifiedasaphosphorylatingandnactivatingglycogensynthase.Twoisoforms,alpha(GSK3A;MIM606784)andbeta,showahighdegreeofaminoacidhomology(StambolicandWoodgett,1994[PubMed7980435]).GSK3Bisinvolvedinenergymetabolism,neuronalcelldevelopment,andbodypatternformation(Plyteetal.,1992[PubMed1333807]).[suppliedbyOMIM].
GeneSymbol	GSK3B EC2.7.11.26
PurificationMethod	ProteinAaffinitypurified
UniProtNumber	P49841
UniProtSummary	FUNCTION:ParticipatesintheWntsignalingpathway.Implicatedinthehormonalcontrolofseveralregulatoryproteinsincludingglycogensynthase,MYBandthetranscriptionfactorJUN.PhosphorylatesJUNatsitesproximaltoitsDNA-bindingdomain,therebyreducingitsaffinityforDNA.PhosphorylatesMUC1inbreastcancercells,anddecreasestheinteractionofMUC1withCTNNB1/beta-catenin. CATALYTICACTIVITY:ATP+[tauprotein]=ADP+[tauprotein]phosphate. ENZYMEREGULATION:InhibitedwhenphosphorylatedbyAKT1. SUBUNIT:Monomer(Bysimilarity).InteractswithCABYR,MUC1,NINandPRUNE. ALTERNATIVEPRODUCTS:2namedisoforms[FASTA]producedbyalternativesplicing.
MolecularWeight	Thisantibodydetectsastrong47kDaprotein.

PhysicochemicalInformation

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Millipore/07-1413 | Anti-GSK-3b Antibody, a.a. 335-349/07-1413/50 µg

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