當前位置： Millipore >>> Millipore/07-1420 | Anti-VEGF Antibody/07-1420/50 µg

Millipore/07-1420 | Anti-VEGF Antibody/07-1420/50 µg

價格: ￥3444.00 市場價: 5740.00

打印產品信息

貨號: 07-1420

品牌: Millipore

規格

默認

數量

庫存(0)

特別提示

代購產品：無質量問題不接受退換貨，下單前請仔細核對信息。
下單后請及時聯系客服核對商品價格，訂單生效后再付款。

立即購買加入購物車

收藏商品

資深產品顧問

咨詢顧問

全國免費服務熱線

4000-520-616

自營商城一站式服務
廠家直采剔除溢價
品質甄選正品保證
嚴控流程只做188精品
極速物流如約送貨

詳情
使用說明
常見問題

Description
CatalogueNumber	07-1420
Replaces	AB2142P
Description	Anti-VEGFAntibody
AlternateNames	VascularpermeABIlityfactor
BackgroundInformation	VEGF(Vascularendothelialgrowthfactor,VEGFA,VEGF-A),adimericligand,isamongthemostpotentangiogenicmitogens.VEGFissecretedbytumorcellsandothercellsexposedtohypoxia.VEGFisahighlyspecificmitogenforvascularendothelialcells.SevenVEGFisoforms(a,b,c,d,e,f,g)aregeneratedasaresultofalternativesplicingfromasingleVEGFgene.ThemostcommonlystudiedisoformsareVEGF121,VEGF165,andVEGF189(f,dandb,respectively)AllsevenisoformsdifferintheirmolecularmassandinBIOLOGicalpropertiessuchastheirabilitytobindtocell-surfaceheparan-sulfateproteoglycans.TheexpressionofVEGFispotentiatedandissecretedbytumorcellsinresponsetohypoxia,byactivatedoncogenes,andbyavarietyofcytokines.VEGFinducesangiogenesisaswellaspermeabilizationofbloodvessels,andplaysacentralroleintheregulationofvasculogenesis.VEGFexpressioncorrelatestothedegreeoftumorvascularizationandwithincreasedmetastaticrisk.Additionally,VEGFinducesendothelialcellproliferation,promotescellmigration,andinhibitsapoptosis.Consequently,inhibitionofVEGFsignalingabrogatesthedevelopmentofawidevarietyoftumors.

ProductInformation
Format	AffinityPurified
Control	Huveccelllysate
Presentation	AffinitypurifiedrabbitpolyclonalIgGemployingimmobilizedmouseVEGFmatrix.Antibodysolution(1mg/ml)waslyophilizedfromPBS,pH7.2.Reconstitutewithsteriledistilledwater.

StorageandShippingInformation
StorageConditions	Reconstitutedantibody,ataconcentrationof≥0.2mg/mL,isstableforatleastsixweeksat2-8oC.Aliquotsstoredat-20oCarestableforatleastoneyearfromdateofreceipt. HandlingRecommendations:Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	Anti-VEGFAntibodydetectslevelofVEGF&hasbeenpublished&validatedforuseinWB,IH(P),ELISA.
KeyApplications	WesternBlotting Immunohistochemistry(Paraffin) ELISA
ApplicationNotes	Immunohistochemisty(paraffin):VEGFstaininginmouseplacenta,tissuewaspretreatedwithcitratebuffer,pH6.0.Apreviouslotofantibodywasdilutedto1:100,usingIHC-Select?detectionwithHRP-DAB. Neutralization:Toyieldone-halfmaximalinhibition[ND50]ofthebiologicalactivityofmouseVEGF(50.0ng/mL),aconcentrationof1.0-2.0μg/mLofapreviouslotofthisantibodywasrequired. ELISA:Aconcentrationofatleast0.5μg/mL(100μL/well)isrequiredtodetect0.2-0.4ng/wellofrecombinantmouseVEGFusingapreviouslotofthisantibody. Optimalworkingdilutionsmustbedeterminedbytheenduser.

BiologicalInformation
Immunogen	Highlypure(>98%)recombinantmouseVascularEndothelialGrowthFactor.
Host	Rabbit
Specificity	RecognizesVascularEndothelialGrowthFactor(VEGF),asecretedhomodimericproteinsecretedbyavarietyofvascularizedtissues.ThereportedactivitiesofVEGFincludestimulationofendothelialcellgrowth,angiogenesis,andcapillarypermeability.
Isotype	IgG
SpeciesReactivity	Human Mouse
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_001025366.1
EntrezGeneSummary	ThisgeneisamemberofthePDGF/VEGFgrowthfactorfamilyandencodesaproteinthatisoftenfoundasadisulfidelinkedhomodimer.Thisproteinisaglycosylatedmitogenthatspecificallyactsonendothelialcellsandhasvariouseffects,includingmediatingincreasedvascularpermeability,inducingangiogenesis,vasculogenesisandendothelialcellgrowth,promotingcellmigration,andinhibitingapoptosis.ElevatedlevelsofthisproteinislinkedtoPOEMSsyndrome,alsoknownasCrow-Fukasesyndrome.Mutationsinthisgenehavebeenassociatedwithproliferativeandnonproliferativediabeticretinopathy.Alternativelysplicedtranscriptvariants,encodingeitherfreelysecretedorcell-associatedisoforms,havebeencharacterized.Thereisalsoevidencefortheuseofnon-AUG(CUG)translationinitiationsitesupstreamof,andin-framewiththefirstAUG,leADIngtoadditionalisoforms.[providedbyRefSeq].
GeneSymbol	VEGFA VPF VEGF-A VEGF
PurificationMethod	AffinityPurfied
UniProtNumber	P15692
UniProtSummary	FUNCTION:Growthfactoractiveinangiogenesis,vasculogenesisandendothelialcellgrowth.Inducesendothelialcellproliferation,promotescellmigration,inhibitsapoptosis,andinducespermeabilizationofbloodvessels.BindstotheVEGFR1/Flt-1andVEGFR2/Kdrreceptors,heparansulfateandheparin.Neuropilin-1bindsisoformsVEGF-165andVEGF-145. SUBUNIT:Homodimer;disulfide-linked.AlsofoundasheterodimerwithPlGF(Bysimilarity). SUBCELLULARLOCATION:Secreted.Note=VEGF121isacidicandfreelysecreted.VEGF165ismorebasic,hasheparin-bindingpropertiesand,althoughasignicantproportionremainscell-associated,mostisfreelysecreted.VEGF189isverybasic,itiscell-associatedaftersecretionandisboundavidlybyheparinandtheextracellularmatrix,althoughitmaybereleasedasasolubleformbyheparin,heparinaseorplasmin. ALTERNATIVEPRODUCTS:10namedisoforms[FASTA]producedbyalternativesplicing.
MolecularWeight	27kDa

PhysicochemicalInformation

Dimensions

MaterialsInformation

MaterialsInformation

售后保障

螞蟻淘生物188，秉承螞蟻淘一貫的嚴謹態度，由螞蟻淘公司專業人員負責品控、采購、物流、銷售、售后，保障正品優質。以“快速好省，為科研提供好產品、好價格”為理念，直接鏈接原廠家，從全國各地原制造商嚴格挑選188款科研精品，剔除品牌溢價，188生物新電商，把好的產品帶給科研！? 力求給你最優質的商品。

Q：生物188產品正品保障嗎？
A：生物188質量把控人員具有十年的從業經驗，在業界享有良好的口碑；自營商城，直接從廠家采購，自己的團隊負責國際物流和清關，中間沒有第三方，所有流程嚴格把控，100%保證正品，假一罰十。

Q：下單后可以修改訂單嗎？
A：下單后的商品付款之前可以修改；訂單付款成功，需要聯系我們客服進行修改；客服電話：4000-520-616

Q：可以開發票嗎？
A：本網站所售商品都是正規清關，均開具16%正規發票，發票金額含配送費金額，另有說明的除外。

Q：商品幾天可以發貨？
A：生物188商品，全部現貨銷售，付款后即可發貨,一般一周內送達！

Q：如何聯系商家？
A：有任何問題夠可以電話咨詢我們，全國24小時免費服務熱線：4000-520-616 或聯系我們的在線客服QQ：1570468124

Q：收到的商品少了/發錯了怎么辦？
A：同個訂單購買多個商品可能會分為一個以上包裹發出，可能不會同時送達，建議查看訂單詳情是否是部分發貨狀態；如未收到，可聯系在線客服或者致電4000-520-616。

Q：退換貨/維修需要多長時間？
A：一般情況下，退貨處理周期為客戶收到產品一個月內（以快遞公司顯示簽收時間為準），包裝規格、數量、品種不符，外觀毀損、短缺或缺陷，請在收到貨24小時內申請退換貨；特殊商品以合同條款為準。

24小時熱銷榜

Jackson/Peroxidase AffiniPure Goat Anti-Mouse IgG (H+L)/2.0 ml/115-035-003
￥830.00
Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
￥830.00
Qubit? dsDNA BR Assay Kit Q32853現貨
￥2000.00
Parafilm M封口膜/PM996/4x125/整箱
￥1296.00

Millipore/07-1420 | Anti-VEGF Antibody/07-1420/50 µg

客戶服務

何為188

關注188微信公眾號