| Immunogen | 18aminoacidpeptidesequencewithintheextracellular,N-terminusofhumanTie-2 | 
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. | 
| Host | Rabbit | 
| Specificity | RecognizeshumanTunicainternalendothelialcellkinase(TIE-2),alsodescribedasAngiopoietin-1receptor,p140TEK,ortyrosineproteinkinasereceptor.Thepeptidesequenceusedasimmunogenis100%conservedinhuman,rat,mouse,and94%inbovine. | 
| SpeciesReactivity |  | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| GeneSymbol | - CD202B
 - CD202b
 - EC2.7.10.1
 - OTTHUMP00000021167
 - TIE-2
 - TIE2
 - VMCM
 - VMCM1
 - hTIE2
 
  | 
| PurificationMethod | AffinityPurfied | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.Itmayconstitutetheearliestmammalianendothelialcelllineagemarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation. CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. SUBUNITSTRUCTURE:InteractswithPTPRB. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney. PTM:Phosphorylated.PhosphorylationisinducedbyANGPT1andANGPT2.ANGPT1-inducedphosphorylationisimpairedduringhypoxia.DephosphorylatedbyPTPRB. INVOLVEMENTINDISEASE:DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels. SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily. Contains3EGF-likedomains. Contains3fibronectintype-IIIdomains. Contains2Ig-likeC2-type(immunoglobulin-like)domains. Contains1proteinkinasedomain. | 
| MolecularWeight | Approx.126kDa |