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            當前位置 : Millipore >>> Millipore/07-1448 | Anti-WAVE-1 Antibody/07-1448/100 µg
            Millipore/07-1448 | Anti-WAVE-1 Antibody/07-1448/100 µg
            • Millipore/07-1448 | Anti-WAVE-1 Antibody/07-1448/100 µg

            Millipore/07-1448 | Anti-WAVE-1 Antibody/07-1448/100 µg

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            貨號: 07-1448
            品牌: Millipore
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              • Description
                CatalogueNumber07-1448
                ReplacesAB4095
                DescriptionAnti-WAVE-1Antibody
                AlternateNames
                • ProteinWAVE-1
                • Verprolinhomologydomain-containingprotein1
                • WASproteinfamily,member1
                • WASPfamilyproteinmember1
                • Wiskott-Aldrichsyndromeproteinfamilymember1
                • homologyofdictyosteliumscar1
                BackgroundInformationRecognizesWAVE1(Wiskott-Aldrichsyndromeproteinfamilymember1,WASP-familyproteinmember1).WAVE1isadownstreameffectormoleculeinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactinCytoskeleton.WAVE1bindsactinandARP2/3complex.ItbindstheARP2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain.
                ProductInformation
                FormatAffinityPurified
                Control
                • RAW264.7celllysat
                PresentationPurifiedrabbitpolyclonalinbuffercontaining0.02Mphosphatebuffer,0.25MNaCl,with0.1%sodiumazide.
                StorageandShippingInformation
                StorageConditionsMaintainat2-8oCinundilutedaliquotsforupto12monthsfromdateofreceipt.
                Applications
                ApplicationThisAnti-WAVE-1AntibodyisvalidatedforuseinWBforthedetectionofWAVE-1.
                KeyApplications
                • WesternBlotting
                BIOLOGicalInformation
                ImmunogenSyntheticpeptidecorrespondingtoaninternalaminoacidsequenceofhumanWAVE1.Immunogensequenceisconservedinratandmouse.
                ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
                HostRabbit
                SpecificityThisantibodyrecognizesaninternalaminoacidsequenceofWAVE-1.
                SpeciesReactivity
                • Human
                • Mouse
                SpeciesReactivityNoteReactswithmouseandhuman.Reactivitywithotherspecieshasnotbeendetermined.
                AntibodyTypePolyclonalAntibody
                EntrezGeneNumber
                EntrezGeneSummaryTheproteinencodedbythisgene,amemberoftheWiskott-Aldrichsyndromeprotein(WASP)-family,playsacriticalroledownstreamofRac,aRho-familysmallGTPase,inregulatingtheactincytoskeletonrequiredformembraneruffling.IthasbeenshowntoassociatewithanactinnucleationcoreArp2/3complexwhileenhancingactinpolymerizationinvitro.Wiskott-Aldrichsyndromeisadiseaseoftheimmunesystem,likelyduetodefectsinregulationofactincytoskeleton.Multiplealternativelysplicedtranscriptvariantsencodingthesameproteinhavebeenfoundforthisgene.
                GeneSymbol
                • KIAA0269
                • OTTHUMP00000016990
                • SCAR1
                • WAVE
                • WAVE1
                • FLJ31482
                PurificationMethodAffinityPurfied
                UniProtNumber
                UniProtSummaryFUNCTION:DownstreameffectormoleculesinvolvedinthetransmissionofsignalsfromtyrosinekinasereceptorsandsmallGTPasestotheactincytoskeleton.
                SUBUNITSTRUCTURE:ComponentoftheWAVE1complexcomposedofABI2,CYFIP2,C3orf10/HSPC300,NCKAP1andWASF1/WAVE1.CYFIP2bindstoactivatedRAC1whichcausesthecomplextodissociate,releasingactivatedWASF1.ThecomplexcanalsobeactivatedbyNCK1Bysimilarity.BindsactinandtheArp2/3complex.InteractswithBAIAP2.
                SUBCELLULARLOCATIION:Cytoplasm?cytoskeleton.Note:Dot-likepatterninthecytoplasm.ConcentratedinRac-regulatedmembrane-rufflingareas.
                TISSUESPECIFICITY:Highlyexpressedinbrain.Lowlyexpressedintestis,ovary,colon,kidney,pancreas,thymus,smallintestineandperipheralblood.
                DOMAIN:BindstheArp2/3complexthroughtheC-terminalregionandactinthroughverprolinhomology(VPH)domain.
                SEQUENCESIMILARITIES:BelongstotheSCAR/WAVEfamily.
                Contains1WH2domain.
                MolecularWeightApprox.62kDa
                PhysicochemicalInformation
                Dimensions
                MaterialsInformation
                MaterialsInformation
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