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Millipore/07-1596 | Anti-SIRT3 (CT) Antibody/07-1596/100 µg

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貨號: 07-1596

品牌: Millipore

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Description
CatalogueNumber	07-1596
Description	Anti-SIRT3(CT)Antibody
AlternateNames	SIR2-likeprotein3,mitochondrialnicotinamideadeninedinucleotide-dependentdeacetylase silentmatingtypeinformationregulation2,S.cerevisiae,homolog3 sir2-like3 sirtuin(silentmatingtypeinformationregulation2homolog)3(S.cerevisiae) sirtuin(silentmatingtypeinformationregulation2,S.cerevisiae,homolog)3 sirtuin3 sirtuintype3
BackgroundInformation	SIRT3isamemberoftheclassIsirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.SIRT3islocatedinthemitochondriaandhasbeenimplicatedinregulatingmetabolicprocesses.EndogenousSIRT3isasolubleproteinlocatedinthemitochondrialmatrix.OverexpressionofSirt3inculturedcellsincreasesrespirationanddecreasestheproductionofreactiveoxygenspecies.FastingincreasesSirt3expressioninwhiteandbrownADIposetissue.AlongerformofSIRT3ispresentinthenucleuswhereitexhibitshistonedeacetylaseactivity.SIRT3protectscardiomyocytesfromstressmediatedcelldeathduetodeacetylationofanuclearfactor,Ku-70.

ProductInformation
Format	Purified
Control	C2C12celllysate
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.09%NaN3.

StorageandShippingInformation
StorageConditions	Stablefor6monthsat2-8°Cfromdateofreceipt.Forlongtermstorage,storeat-20oC.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.

Applications
Application	Anti-SIRT3(C-terminus)AntibodyisaRabbitPolyclonalAntibodyfordetectionofSIRT3(C-terminus)alsoknownsirtuin3&hasbeenvalidatedinWB,ELISA&IHC.
KeyApplications	WesternBlotting ELISA Immunohistochemistry
ApplicationNotes	ELISA: ThisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforELISA(1:1000). Immunohistochemistry: Thisantibodyhasbeenshownbyanoutsidelaboratorytobesuitableforhistochemistryusinghumanhepatocarcinomatissue(1:50–1:100).

BIOLOGicalInformation
Immunogen	TheimmunogenwasapeptidecorrespondingtheC-terminalregionofhumanSIRT3.
Epitope	C-terminus
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisantibodyrecognizesSIRT3.Endogenouslevelsofthisproteinvaryamongcelllines;theproteinwaseasilydetectedinRAW264.7andC2C12cellsbutonlyweaklydetectedinHeLacells,andnotdetectedinJurkat,HEK293orPC3cells.
SpeciesReactivity	Mouse Human
SpeciesReactivityNote	Human,Mouse.Nottestedinotherspecies.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_036371
EntrezGeneSummary	Thisgeneencodesamemberofthesirtuinfamilyofproteins,homologstotheyeastSir2protein.Membersofthesirtuinfamilyarecharacterizedbyasirtuincoredomainandgroupedintofourclasses.Thefunctionsofhumansirtuinshavenotyetbeendetermined;however,yeastsirtuinproteinsareknowntoregulateepigeneticgenesilencingandsuppressrecombinationofrDNA.Studiessuggestthatthehumansirtuinsmayfunctionasintracellularregulatoryproteinswithmono-ADP-ribosyltransferaseactivity.TheproteinencodedbythisgeneisincludedinclassIofthesirtuinfamily.Twoalternativelysplicedtranscriptvariantsthatencodedifferentproteinshavebeendescribedforthisgene.[providedbyRefSeq].
GeneSymbol	SIR2L3 hSIRT3 EC3.5.1
PurificationMethod	Purified
UniProtNumber	Q9NTG7
UniProtSummary	FUNCTION:NAD-dependentdeacetylase.DespitesomeABIlitytodeacetylatehistonesinvitro,itisunlikelyinvivo. CatalyticactivityNAD++anacetylprotein=nicotinamide+O-acetyl-ADP-ribose+aprotein.Ref.4Ref.5 CofactorBinds1zincionpersubunitBysimilarity. SUBCELLULARLOCATION:Mitochondrionmatrix.Ref.4Ref.5 TISSUESPECIFICITY:Widelyexpressed.Ref.5Ref.1 PTM:Processedbymitochondrialprocessingpeptidase(MPP)togivea28kDaproduct.Suchprocessingisprobablyessentialforitsenzymaticactivity. SEQUENCESIMILARITY:Belongstothesirtuinfamily. Contains1deacetylasesirtuin-typedomain.
MolecularWeight	44kDa

PhysicochemicalInformation

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Millipore/07-1596 | Anti-SIRT3 (CT) Antibody/07-1596/100 µg

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