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Millipore/07-1653 | Anti-Beta Catenin Antibody/07-1653/100 µg

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貨號: 07-1653

品牌: Millipore

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Description
CatalogueNumber	07-1653
Replaces	04-1002
Description	Anti-BetaCateninAntibody
BackgroundInformation	Cateninsareproteinsfoundincomplexeswithcadherincelladhesionmoleculesofanimalcells.Thefirsttwocateninsthatwereidentifiedbecameknownasα-cateninandβ-catenin.α-catenincanbindtoβ-cateninandcanalsobindactin.β-cateninbindsthecytoplasmicdomainofsomecadherins.Whenβ-cateninwassequenceditwasfoundtobeamemberofthearmADIllofamilyofproteins.Theseproteinshavemultiplecopiesoftheso-calledarmadillorepeatdomainwhichisspecializedforprotein-proteinbinding.Anincreaseinβ-cateninproductionhasbeennotedinthosepeoplewhohaveBasalCellCarcinomaandleadstotheincreaseinproliferationofrelatedtumors.Whenβ-cateninisnotassociatedwithcadherinsandα-catenin,itcaninteractwithotherproteinssuchasCateninBetaInteractingProtein1(ICAT)andadenomatosispolyposiscoli(APC).Recentevidencesuggeststhatβ-cateninplaysanimportantroleinvariousaspectsofliverBIOLOGyincludingliverdevelopment(bothembryonicandpostnatal),liverregenerationfollowingpartialhepatectomy,HGF-inducedhepatpomegaly,liverzonation,andpathogenesisoflivercancer

ProductInformation
Format	AffinityPurified
Control	HEK293lysate
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine,(pH7.4),150mMNaCl,with0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8oCfromdateofreceipt.

Applications
Application	Anti-BetaCateninAntibodyisanantibodyagainstBetaCateninforuseinWB.
KeyApplications	WesternBlotting

BiologicalInformation
Immunogen	KLH-conjugatedsyntheticlinearpeptidecorrespondingtobetacatenin.
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	Thisantibodydetectsbetacateninregardlessofphosphorylationstate.
SpeciesReactivity	Human Mouse Xenopus Chicken Rat
SpeciesReactivityNote	Testedonhuman.Predictedtocross-reactwithmouse,rat,xenopusandchickenbasedonsequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001091679
EntrezGeneSummary	Beta-cateninisanadherensjunctionprotein.Adherensjunctions(AJs;alsocalledthezonulaadherens)arecriticalfortheestablishmentandmaintenanceofepitheliallayers,suchasthoseliningorgansurfaces.AJsmediateadhesionbetweencells,communicateasignalthatneighboringcellsarepresent,andanchortheactinCytoskeleton.Inservingtheseroles,AJsregulatenormalcellgrowthandbehavior.Atseveralstagesofembryogenesis,woundhealing,andtumorcellmetastasis,cellsformandleaveepithelia.Thisprocess,whichinvolvesthedisruptionandreestablishmentofepithelialcell-cellcontacts,mayberegulatedbythedisassemblyandassemblyofAJs.AJsmayalsofunctioninthetransmissionofthe"contactinhibition"signal,whichinstructscellstostopdividingonceanepithelialsheetiscomplete.[suppliedbyOMIM]
GeneSymbol	CTNNB
PurificationMethod	AffinityPurfied
UniProtNumber	P35222
UniProtSummary	FUNCTION:InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway. SUBUNITSTRUCTURE:Twoseparatepoolsarefoundinthecytoplasm:oneisPSEN1/cadherin/catenincomplexwhichanchorstotheactincytoskeleton.TheotherpoolispartofalargecomplexcontainingAXIN1,AXIN2,APC,CSNK1A1andGSK3BthatpromotesphosphorylationonN-terminalSerandThrresiduesandubiquitinationofCTNNB1viaBTRCanditssubsequentdegradationbytheproteasome.Wnt-dependentactivationofDVLantagonizestheactionofGSK3B.WhenGSK3Bactivityisinhibitedthecomplexdissociates,CTNNB1isdephosphorylatedandisnolongertargetedfordestruction.ThestABIlizedproteintranslocatestothenucleus,whereitbindsTCF/LEF-1familymembers,TBP,BCL9andpossIBLyalsoRUVBL1andCHD8.BindsCTNNBIPandEP300.CTNNB1formsaternarycomplexwithLEF1andEP300thatisdisruptedbyCTNNBIP1bindingBysimilarity.InteractswithTAX1BP3(viathePDZdomain);thisinteractioninhibitsthetranscriptionalactivityofCTNNB1Bysimilarity.InteractswithAJAP1,BAIAP1,CARM1,CTNNA3,CXADRandPCDH11Y.BindsSLC9A3R1.InteractswithGLIS2andMUC1.InteractswithSLC30A9.InteractswithXIRP1Bysimilarity.InteractswithPTPRU(viathecytoplasmicjuxtamembranedomain). SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cytoplasm?cytoskeleton.Note=Cytoplasmicwhenitisunstabilized(highlevelofphosphorylation)orboundtoCDH1.Translocatestothenucleuswhenitisstabilized(lowlevelofphosphorylation).InteractionwithGLIS2andMUC1promotesnucleartranslocation. TISSUESPECIFICTY:Expressedinseveralhairfolliclecelltypes:basalandperipheralmatrixcells,andcellsoftheouterandinnerrootsheats.Expressedincolon. PTM:PhosphorylationbyGSK3BrequirespriorphosphorylationofSer-45byanotherkinase.PhosphorylationproceedsthenfromThr-41toSer-37andSer-33. EGFstimulatestyrosinephosphorylation.PhosphorylationonTyr-654decreasesCDH1bindingandenhancesTBPbinding. UbiquitinatedbyaE3ubiquitinligasecomplexcontainingUBE2D1,SIAH1,CACYBP/SIP,SKP1A,APCandTBL1XProbable.Itsubiquitinationleadstoitssubsequentproteasomaldegradation. INVOLVEMENTINDISEASE:ActivatingmutationsinCTNNB1haveoncogenicactivityresultingintumordevelopment.Somaticmutationsarefoundinvarioustumortypes,includingcoloncancers,ovarianandprostatecarcinomas,hepatoblastoma(HB),hepatocellularcarcinoma(HCC).HBsaremalignantembryonaltumorsmainlyaffectingyoungchildreninthefirstthreeyearsoflife. DefectsinCTNNB1areacauseofpilomatrixoma(PTR)[MIM:132600];acommonbenignskintumor. DefectsinCTNNB1areacauseofmedulloblastoma(MDB)[MIM:155255].MDBisamalignant,invasiveembryonaltumorofthecerebellumwithapreferentialmanifestationinchildren. AchromosomalrearrangementinvolvingCTNNB1maybeacauseofsalivaryglandpleiomorphicadenomas(PA)[181030].Pleiomorphicadenomasarethemostcommonbenignepithelialtumorsofthesalivarygland.Translocationt(3;8)(p21;q12)withPLAG1. SEQUENCESIMILARITIES:Belongstothebeta-cateninfamily. Contains12ARMrepeats.
MolecularWeight	~92kDa

PhysicochemicalInformation

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Millipore/07-1653 | Anti-Beta Catenin Antibody/07-1653/100 µg

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