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Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg

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貨號: 07-218

品牌: Millipore

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Description
CatalogueNumber	07-218
Replaces	04-1046
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-Notch1Antibody,extracellulardomain
BackgroundInformation	TheNotchproteinfamilyisagroupofhighlyconservedproteinsimportantinthedeterminationofcellfateandmaintenanceofProgenitorsinmanydevelopmentalsystems.Thisfamilyofproteinsfunctionbothasmembranecellreceptorsandastranscriptionfactors.ActivationofNotchbycell-cellinteractionscausesatranscriptioninhibitoryeffectthatenablesinhibitionofdifferentiationinsomecellsbutnotinothers.Asaconsequence,somecellsadoptaparticularfatewhileotherprogenitorsremainuncommitted.TheNotchproteinisimportantincellfateduringmyogenesis,neurogenesis,oogenesis,andwingandeyedevelopmentinDrosophila.Inmammals,fourNotchgeneswereidentified(Notch1-4)thatareexpressedinawidevarietyofcellsandplayacrucialroleindifferentiationanddevelopment.

ProductInformation
Format	Purified
Control	L/N17transfectedNotch1celllysate
Presentation	ProteinApurifiedimmunoglobulinpresentedin0.1MTris-Glycine,0.15MNaCl,and0.05%SodiumAzide,pH7.4

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	Anti-Notch1Antibody,extracellulardomainisahighqualityRabbitPolyclonalAntibodyforthedetectionofNotch1&hasbeenvalidatedinWB.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	N-terminalGSTfusionproteincorrespondingtoresidues381-853ofratNotch1
Host	Rabbit
Specificity	Notch1
Isotype	IgG
SpeciesReactivity	Rat Mouse
SpeciesReactivityNote	Usedinmouseinthefollowingpublication:Gulino,R.,etal,EuropeanJournalofNeuroscience,Vol.31,pp.1423–1434,2010.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_017617
EntrezGeneSummary	ThisgeneencodesamemberoftheNotchfamily.MembersofthisType1transmembraneproteinfamilysharestructuralcharacteristicsincludinganextracellulardomainconsistingofmultipleepidermalgrowthfactor-like(EGF)repeats,andanintracellulardomainconsistingofmultiple,differentdomaintypes.Notchfamilymembersplayaroleinavarietyofdevelopmentalprocessesbycontrollingcellfatedecisions.TheNotchsignalingnetworkisanevolutionarilyconservedintercellularsignalingpathwaywhichregulatesinteractionsbetweenphysicallyadjacentcells.InDrosophilia,notchinteractionwithitscell-boundligands(delta,serrate)establishesanintercellularsignalingpathwaythatplaysakeyroleindevelopment.Homologuesofthenotch-ligandshavealsobeenidentifiedinhuman,butpreciseinteractionsbetweentheseligandsandthehumannotchhomologuesremaintobedetermined.Thisproteiniscleavedinthetrans-Golginetwork,andpresentedonthecellsurfaceasaheterodimer.Thisproteinfunctionsasareceptorformembraneboundligands,andmayplaymultiplerolesduringdevelopment.
GeneSymbol	NOTCH1 notch1 hN1 TAN1
PurificationMethod	ProteinAchromatography
UniProtNumber	P46531
UniProtSummary	FUNCTION:SwissProt:P46531#Functionsasareceptorformembrane-boundligandsJagged1,Jagged2andDelta1toregulatecell-fatedetermination.Uponligandactivationthroughthereleasednotchintracellulardomain(NICD)itformsatranscriptionalactivatorcomplexwithRBP-Jkappaandactivatesgenesoftheenhancerofsplitlocus.Affectstheimplementationofdifferentiation,proliferationandapoptoticprograms.Maybeimportantfornormallymphocytefunction.Inalteredform,maycontributetotransformationorprogressioninsomeT-cellneoplasms.InvolvedinthematurationofbothCD4+andCD8+cellsinthethymus.MaybeimportantforfolliculardifferentiationandpossIBLycellfateselectionwithinthefollicle.Duringcerebellardevelopment,mayfunctionasareceptorforneuronalDNERandmaybeinvolvedinthedifferentiationofBergmannglia(Bysimilarity). SIZE:2556aminoacids;272500Da SUBUNIT:HeterodimerofaC-terminalfragmentN(TM)andanN-terminalfragmentN(EC)whichareprobablylinkedbydisulfidebonds.InteractswithDNER,DTX1,DTX2andRBPSUH.AlsointeractswithMAML1,MAML2andMAML3whichactastranscriptionalcoactivatorsforNOTCH1. SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein(Bysimilarity).&Notch1intracellulardomain:Nucleus(Bysimilarity).Note=FollowingproteolyticalprocessingNICDistranslocatedtothenucleus(Bysimilarity). TISSUESPECIFICITY:Infetaltissuesmostabundantinspleen,brainstemandlung.Alsopresentinmostadulttissueswhereitisfoundmainlyinlymphoidtissues. PTM:Synthesizedintheendoplasmicreticulumasaninactiveformwhichisproteolyticallycleavedbyafurin-likeconvertaseinthetrans-Golginetworkbeforeitreachestheplasmamembranetoyieldanactive,ligand-accessibleform.CleavageresultsinaC-terminalfragmentN(TM)andaN-terminalfragmentN(EC).Followingligandbinding,itiscleavedbyTNF-alphaconvertingenzyme(TACE)toyieldamembrane-associatedintermediatefragmentcallednotchextracellulartruncation(NEXT).Thisfragmentisthencleavedbypresenilindependentgamma-secretasetoreleaseanotch-derivedpeptidecontainingtheintracellulardomain(NICD)fromthemembrane(Bysimilarity).&Phosphorylated(Bysimilarity). DISEASE:SwissProt:P46531#NOTCH1truncationisassociatedwithT-cellacutelymphoblasticleukemia.&DefectsinNOTCH1areacauseofaorticvalvedisease[MIM:109730].Thedisorderconsistsofanearlydevelopmentaldefectintheaorticvalveandalaterde-repressionofcalciumdepositionthatcausesprogressiveaorticvalvedisease.CalcificationoftheaorticvalveisthethirdleADIngcauseofheartdiseaseinadults.Theincidenceincreaseswithage,anditisoftenassociatedwithabicUSPidaorticvalvepresentin1-2%ofthepopulation. SIMILARITY:SwissProt:P46531##BelongstotheNOTCHfamily.&Contains5ANKrepeats.&Contains36EGF-likedomains.&Contains3LNR(Lin/Notch)repeats.
MolecularWeight	260kDa

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Millipore/07-218 | Anti-Notch1 Antibody, extracellular domain/07-218/100 µg

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