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Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg

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貨號: 07-371

品牌: Millipore

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Description
CatalogueNumber	07-371
Replaces	MABE15
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-HistoneH2BAntibody
AlternateNames	H2B HistoneH2B H2Bhistonefamily,memberQ histone2 H2be histonecluster2 H2be
BackgroundInformation	HistoneH2Btype3-B(UniProt:Q8N257;alsoknownasH2Btype12)isencodedbytheHIST3H2BBgene(GeneID:128312)inhuman.HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofchromatinineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichDNAiswrappedinrepeatingunits,callednucleosomes,whichlimitsDNAaccessibilitytothecellularmachineries,whichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.HistoneH2Bisoneofthemainhistoneproteinsinvolvedinthestructureofchromatinineukaryoticcells.FeaturingamainglobulardomainandalongNterminaltail,H2Bisinvolvedwiththestructureofthenucleosomesofthe"beadsonastring"structure.HistoneH2BcanbemonoubiquitinatedonLysine123byRAD6/UBC2-BRE1complextoformH2BK123Ub1complexthatgivesaspecifictagforepigenetictranscriptionalactivationandisalsoaprerequisiteforH3K4meandH3K79meformation.H2BK123ub1isreportedtomodulatestheformationofdouble-strandbreaksduringmeiosisandisarequiredforDNA-damagecheckpointactivation.HistoneH2BisphosphorylatedbySTE20toformH2BS10phduringprogressionthroughmeioticprophaseandmaybecorrelatedwithchromosomecondensation.HistoneH2BcanundergoacetylationbyGCN5,acomponentoftheSAGAcomplex,toformH2BK11acandH2BK16ac.AcetylationofN-terminallysinesandparticularlyformationofH2BK11acK16achasapositiveeffectontranscription.

ProductInformation
Format	Purified
Control	AcidextractfromeithersodiumbutyrateorcolcemidtreatedHeLacells.
Presentation	Purifiedrabbitpolyclonalantibodyinbuffercontaining0.02Mphosphatebuffer,pH7.6,0.25MNaCl,with0.1%sodiumazideand30%glycerol.

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt.

Applications
Application	Anti-HistoneH2BAntibody,Cat.No.07-371,isahighlyspecificrabbitpolyclonalantibodythattargetsHistoneH2BandhasbeentestedinWesternBlotting.
KeyApplications	WesternBlotting
ApplicationNotes	WesternBlottingAnalysis:1-2μg/mLfromarepresentativelotdetectedHistoneH2BinacidextractofHeLacellstreatedwitheithersodiumbutyrateorcolcemid.

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingto9aminoacidsfromtheC-terminusofhumanHistoneH2Btype3-B.
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisrabbitpolyclonalantibodydetectsHistoneH2Binhumanandchicken.Ittargetsanepitopewithin9aminoacidsfromtheC-terminusregion.
Isotype	IgG
SpeciesReactivity	Chicken Human
SpeciesReactivityNote	Human,Chicken.PredictedtoreactwithYeast,Xenopusbasedon100%sequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_778225
EntrezGeneSummary	Histonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement.
GeneSymbol	GL105 H2B H2B-GL105 H2B.1 H2B.q H2B/q H2BFQ MGC119802 MGC119804 MGC129733 MGC129734 OTTHUMP00000013920
PurificationMethod	ProteinAchromatography
UniProtNumber	Q8N257
UniProtSummary	FUNCTION:SwissProt:Q8N257#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:126aminoacids;13908Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. PTM:MonoubiquitinationofLys-121bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII.&PhosphorylatedonSer-15bySTK4/MST1duringapoptosis;whichfacilitatesapoptoticchromatincondensation.AlsophosphorylatedonSer-15inresponsetoDNAdoublestrandbreaks(DSBs),andincorrelationwithsomatichypermutationandimmunoglobulinclass-switchrecombination. SIMILARITY:SwissProt:Q8N257##BelongstothehistoneH2Bfamily.
MolecularWeight	~17kDaobserved;13.91kDacalculated.Uncharacterizedbandsmaybeobservedinsomelysate(s).

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Millipore/07-371 | Anti-Histone H2B Antibody/07-371/200 µg

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