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            當前位置 : Millipore >>> Millipore/07-577 | Anti-Stargazin/Cacng2 Antibody, CT/07-577/100 µg
            Millipore/07-577 | Anti-Stargazin/Cacng2 Antibody, CT/07-577/100 µg
            • Millipore/07-577 | Anti-Stargazin/Cacng2 Antibody, CT/07-577/100 µg

            Millipore/07-577 | Anti-Stargazin/Cacng2 Antibody, CT/07-577/100 µg

            價格: ¥4440.00 市場價: 7400.00

            貨號: 07-577
            品牌: Millipore
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              • Description
                CatalogueNumber07-577
                BrandFamilyUpstate
                TradeName
                • Upstate
                DescriptionAnti-Stargazin/Cacng2Antibody,CT
                AlternateNames
                • Neuronalvoltage-gatedcalciumchannelgamma-2subunit
                • calciumchannel,voltage-dependent,gammasubunit2
                • voltage-dependentcalciumchannelgamma-2subunit
                BackgroundInformationStargazinbelongstoagroupcalledvoltagegatedcalciumchannels(VGCCs)whicharepresentinmostexcitablecells.StargazinisthoughttostABIlizethecalciumchannelinaninactivated(closed)state.
                Therearefivehighvoltageactivatedcalciumchanneltypes(L,N,P,Q,andR)andonelowvoltageactivatedchanneltype(T).Eachofthesechannelsexistsasaheteromultimerofa1,b,a2/dandgsubunitswiththevoltageactivatedcalciumchannelfunctioncarriedbytheasubunits.VGCCsexertspatialandtemporalcontrolovercellularcalciumconcentrationsandservetomodulateneurotransmitterrelease,hormonesecretion,musclecontraction,electricalactivity,cellmetabolismandproliferation,geneexpression,andneuronalsurvival.
                ProductInformation
                FormatPurified
                Control
                • Braintissue
                PresentationPurifiedrabbitpolyclonalIgGinbuffercontaining0.1MTris-glycine,pH7.4,0.15MNaCl,0.05%sodiumazidebeforetheadditionofglycerolto30%.
                StorageandShippingInformation
                StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
                Applications
                ApplicationThisAnti-Stargazin/Cacng2Antibody,CTisvalidatedforuseinIC,IP,WBforthedetectionofStargazin/Cacng2.
                KeyApplications
                • Immunocytochemistry
                • Immunoprecipitation
                • WesternBlotting
                ApplicationNotesImmunoprecipitation:
                2-5μgofthisantibodyhasbeenreportedbyanindependentlaboratorytoimmunoprecipitateStargazininratP2lysate.
                BIOLOGicalInformation
                ImmunogenKLH-conjugated,syntheticpeptidecorrespondingtoaminoacids305-323(KDSKDSLHANTANRRTTPV)ofratStargazin.
                EpitopeC-terminus
                ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
                HostRabbit
                SpecificityRecognizesStargazin,MW~36-39kDa.
                IsotypeIgG
                SpeciesReactivity
                • Rat
                • Mouse
                SpeciesReactivityNoteRat.Predictedtocross-reactwithmousebasedonsequencesimilarity.
                AntibodyTypePolyclonalAntibody
                EntrezGeneNumber
                EntrezGeneSummaryL-typecalciumchannelsarecomposedoffivesubunits.Theproteinencodedbythisgenerepresentsoneofthesesubunits,gamma,andisoneofseveralgammasubunitproteins.Itisanintegralmembraneproteinthatisthoughttostabilizethecalciumchannelinaninactive(closed)state.Thisproteinissimilartothemousestargazinprotein,mutationsinwhichhavebeenassociatedwithabsenceseizures,alsoknownaspetit-malorspike-waveseizures.ThisgeneisamemberoftheneuronalcalciumchannelgammasubunitgenesubfamilyofthePMP-22/EMP/MP20family.
                GeneSymbol
                • CACNG2
                • MGC138502
                • MGC138504
                • stargazin
                PurificationMethodProteinAPurfied
                UniProtNumber
                UniProtSummaryFUNCTION:SwissProt:Q9Y698#Thoughttostabilizethecalciumchannelinaninactivated(closed)state.
                SIZE:323aminoacids;35966Da
                SUBUNIT:TheL-typecalciumchanneliscomposedoffivesubunits:alpha-1,alpha-2/delta,betaandgamma.InteractswiththePDZdomainsofDLG4/PSD-95andDLG1/SAP97.MayinteractwithGOPC(Bysimilarity).
                SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein.
                TISSUESPECIFICITY:Brain.
                PTM:PhosphorylationofThr-321impairsinteractionwithDLG1andDLG4.
                SIMILARITY:SwissProt:Q9Y698##BelongstothePMP-22/EMP/MP20family.CACNGsubfamily.
                MolecularWeight~36-39kDa
                PhysicochemicalInformation
                Dimensions
                MaterialsInformation
                MaterialsInformation
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