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Millipore/07-606 | Anti-phospho-JAK2 (Tyr1007/1008) Antibody/07-606/200 µg

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貨號: 07-606

品牌: Millipore

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Description
CatalogueNumber	07-606
Replaces	04-1098
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-phospho-JAK2(Tyr1007/1008)Antibody
AlternateNames	Januskinase2 Januskinase2(aproteintyrosinekinase) tyrosine-proteinkinaseJAK2
BackgroundInformation	JAK2(JanusKinase2)belongstotheemergingfamilyofnon-receptorJanustyrosinekinases,whichregulateaspectrumofcellularfunctionsdownstreamofactivatedcytokinereceptorsinthelympho-hematopoieticsystem.Immunologicalstimuli,suchasinterferonsandcytokines,inducerecruitmentofStattranscriptionfactorstocytokinereceptor-associatedJAK2.JAK2thenphosphorylatesproximalStatfactors,whichsubsequentlydimerize,translocatetothenucleusandbindtoCISelementsupstreamoftargetgenepromoterstoregulatetranscription.ThecanonicalJAK/Statpathwayisintegraltomaintaininganormalimmunesystembystimulatingproliferation,differentiation,survivalandhostresistancetopathogens.AlteringJAK/Statsignalingtoreducecytokineinducedpro-inflammatoryresponsesrepresentsanattractivetargetforanti-inflammatorytherapies.WithintheJAK2kinasedomain,thereisaregionthathasconsiderablesequencehomologytotheregulatoryregionoftheinsulinreceptor.Amongavarietyofsites,Tyrosines1007and1008aresitesoftrans-orautophosphorylationinvivoandininvitrokinasereactions.

ProductInformation
Format	Purified
Control	Humanovariancancercells,GM-CSF-treatedTF-1cells.
Presentation	PurifiedrabbitIgGinbuffercontaining0.1MTris-Glycine,0.15MNaCl,0.05%SodiumAzide,pH7.4.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap.

Applications
Application	Anti-phospho-JAK2(Tyr1007/1008)Antibodydetectslevelofphospho-JAK2(Tyr1007/1008)&hasbeenpublished&validatedforuseinWB.
KeyApplications	WesternBlotting

BIOLOGicalInformation
Immunogen	KLH-conjugated,syntheticpeptidecorrespondingtoaminoacidssurroundingphosphotyrosines1007and1008ofhumanJAK2.
Epitope	Tyr1007/1008
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	RecognizesphosphorylatedJAK2,Mr130kDa.
Isotype	IgG
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Humanandmouse.Predictedtocross-reactwithratbasedonsequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_004963
EntrezGeneSummary	Thisgeneproductisaproteintyrosinekinaseinvolvedinaspecificsubsetofcytokinereceptorsignalingpathways.Ithasbeenfoundtobeconstituitivelyassociatedwiththeprolactinreceptorandisrequiredforresponsestogammainterferon.Micethatdonotexpressanactiveproteinforthisgeneexhibitembryoniclethalityassociatedwiththeabsenceofdefinitiveerythropoiesis.
GeneSymbol	JAK2 OTTHUMP00000043260 JAK-2
Modifications	Phosphorylation
PurificationMethod	ProteinAPurfied
UniProtNumber	O60674
UniProtSummary	FUNCTION:SwissProt:O60674#Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction. SIZE:1132aminoacids;130674Da SUBUNIT:InteractswithSIRPA(Bysimilarity).InteractswithIL23R,SKB1andSTAM2. SUBCELLULARLOCATION:Intracytoplasmicmembrane;Peripheralmembraneprotein(Bysimilarity).Note=Whollyintracellular,possIBLymembraneassociated(Bysimilarity). TISSUESPECIFICITY:Expressedinblood,bonemarrowandlymphnode. DOMAIN:SwissProt:O60674Possessestwophosphotransferasedomains.Thesecondoneprobablycontainsthecatalyticdomain(Bysimilarity),whilethepresenceofslightdifferencessuggestadifferentrolefordomain1. DISEASE:SwissProt:O60674#ChromosomalaberrationsinvolvingJAK2arefoundinbothchronicandacuteformsofeosinophilic,lymphoblasticandmyeloidleukemia.Translocationt(8;9)(p22;p24)withPCM1linkstheproteinkinasedomainofJAK2tothemajorportionofPCM1.Translocationt(9;12)(p24;p13)withETV6.&DefectsinJAK2areacauseofsusceptibilitytoBudd-Chiarisyndrome[MIM:600880].Budd-Chiarisyndromeisaspectrumofdiseasestates,includinganatomicabnormalitiesandhypercoagulabledisorders,resultinginhepaticvenousoutflowocclusion.Clinicalmanifestationsobservedinthemajorityofpatientsincludehepatomegaly,rightupperquadrantpain,andaBDominalascites.&DefectsinJAK2areassociatedwithpolycythemiavera(PV)[MIM:263300].PV,themostcommonformofprimarypolycythemia,iscausedbysomaticmutationinasinglehematopoieticstemcellleADIngtoclonalhematopoiesis.PVisamyeloproliferativedisordercharacterizedpredominantlybyerythroidhyperplasia,butalsobymyeloidleukocytosis,thrombocytosis,andsplenomegaly.FamilialcasesofPVareveryrareandusuallymanifestinelderlypatients.&DefectsinJAK2genemaybeacauseofessentialthrombocythemia(ET)[MIM:187950].ETischaracterizedbyelevatedplateletlevelsduetosustainedproliferationofmegakaryocytes,andfrequentlyleadtothromboticandhaemorrhagiccomplications.&DefectsinJAK2areassociatedwithfamilialmyelofibrosis[MIM:254450].Myelofibrosiswithmyeloidmetaplasiaisamyeloproliferativediseasewithannualincidenceof0.5-1.5casesper100,000individualsandageatdiagnosisaround60(anincreasedprevalenceisnotedinAshkenaziJews).Clinicalmanifestationsdependonthetypeofbloodcellaffectedandmayincludeanemia,pallor,splenomegaly,hypermetabolicstate,petechiae,ecchymosis,bleeding,lymphadenopathy,hepatomegaly,portalhypertension.&DefectsinJAK2areacauseofacutemyelogenousleukemia(AML)[MIM:601626].AMLisamalignantdiseaseinwhichhematopoieticprecursorsarearrestedinanearlystageofdevelopment. SIMILARITY:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.&Contains1FERMdomain.&Contains1proteinkinasedomain.&Contains1SH2domain.
MolecularWeight	130kDa

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Millipore/07-606 | Anti-phospho-JAK2 (Tyr1007/1008) Antibody/07-606/200 µg

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