| Immunogen | KLH-conjugated,syntheticpeptidespanningaminoacids7-17(...GATISKKGFKK...)ofhumantestis/spermspecifichistoneH2B | 
| Host | Rabbit | 
| Specificity | histoneH2B,testisvariant | 
| SpeciesReactivity |  | 
| SpeciesReactivityNote | Predictedtocross-reactwithratbasedonsequencehomology | 
| AntibodyType | PolyclonalAntibody | 
| EntrezGeneNumber |  | 
| EntrezGeneSummary | HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.Thisgeneisintronlessandencodesatestis/sperm-specificmemberofthehistoneH2Bfamily.Transcriptsfromthisgenecontainapalindromicterminationelement. | 
| GeneSymbol | - HIST1H2BA
 - H2BFU
 - bA317E16.3
 - STBP
 - TSH2B
 
  | 
| PurificationMethod | Antiserum | 
| UniProtNumber |  | 
| UniProtSummary | FUNCTION:SwissProt:Q96A08#Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SIZE:127aminoacids;14167Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus. TISSUESPECIFICITY:Transcribedexclusivelyintestis,andthecorrespondingproteinisalsopresentinmaturesperm. PTM:MonoubiquitinationofLys-122bytheRNF20/40complexgivesaspecifictagforepigenetictranscriptionalactivationandisalsoprerequisiteforhistoneH3"Lys-4"and"Lys-79"methylation.ItalsofunctionscooperativelywiththeFACTdimertostimulateelongationbyRNApolymeraseII. SIMILARITY:SwissProt:Q96A08##BelongstothehistoneH2Bfamily. | 
| MolecularWeight | Mr15kDa |