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Millipore/07-770 | Anti-acetyl-Histone H2A.Z (Lys8) Antibody | 07-770/07-770/100 µg

價格: ￥5304.00 市場價: 8840.00

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貨號: 07-770

品牌: Millipore

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Description
CatalogueNumber	07-770
Description	Anti-acetyl-HistoneH2A.Z(Lys8)Antibody\|07-770
AlternateNames	H2Ahistonefamily,memberZ H2AZhistone histoneH2A.Z Htz1
BackgroundInformation	H2A.Z,alsoknownasH2AFZ,isavariantofhistoneH2Avariantthatishighlyconservedfromyeasttohumans.Likeotherhistonevariants,H2A.Zisencodedbyauniquegene,resultinginaslightlydivergenttypeofH2Awithspecializedfunctions.H2A.ZisinvolvedinchromatincompactionbystABIlizingthehistoneoctamerwithinthenucleosome.Itpromotesgeneexpressionthroughthecreationofanopendomainofchromatinthatismoreeasilytranscribed.H2A.Zisnonrandomlydistributedthroughoutthegenome,targetedprimarilytopericentricheterochromatin,butexcludedfromtheinactiveXchromosomeandthenucleolus.H2A.Zisassociatedwithbotheuchromatinandfacultativeheterochromatin.DNAmethylationcaninfluencechromatinstructureandeffectgenesilencingbyexcludingH2A.Z,andlikewise,H2A.ZprotectsgenesfromDNAmethylation.Thus,H2A.Zplaysaroleinregulatingheterochromatinsilencingandisinvolvedintranscriptionalcontrol.

ProductInformation
Format	AffinityPurified
Control	Yeastwholecellextract
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
KeyApplications	WesternBlotting
ApplicationNotes	WesternBlot(Snapi.d.)Analysis:4μg/mLfromarepresentativelotdetectedHistoneH2A.Zon10μgofyeastwholecellextract.

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtoyeastHistoneH2A.ZacetylatedatLys8.
Epitope	HistoneH2A.ZacetylatedLys8
Concentration	0.5mg/mL
Host	Rabbit
Specificity	ThisantibodyrecognizesHistoneH2A.ZwhenacetylatedatLys8.
SpeciesReactivity	Human
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_014631
GeneSymbol	H2A.z H2A/z H2AZ H2AFZ
Modifications	Acetylation
PurificationMethod	AffinityPurfied
UniProtNumber	Q12692
UniProtSummary	FUNCTION:VarianthistoneH2AwhichcanreplaceH2Ainsomenucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Thisvariantisenrichedatpromoters,itmaykeeptheminarepressedstateuntiltheappropriateactivationsignalisreceived.Neartelomeres,itmaycounteractgenesilencingcausedbythespreadofheterochromatinproteins.RequiredfortheRNApolymeraseIIandSPT15/TBPrecruitmenttothetargetgenes.Involvedinchromosomestability. SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.H2AoritsvariantH2A.ZformsanheterodimerwithH2B.H2A.ZassociateswiththeVPS72/SWC2subunitoftheSWR1chromatinremodelingcomplex.InteractsalsowithRBP1/DNA-directedRNApolymeraseIIlargestsubunit.InteractswithNAP1. SUBCELLULARLOCATION:Nucleus PTM:AcetylatedbyESA1,acomponentoftheNuA4histoneacetyltransferase(HAT)complex,and/orbyGCN5,acomponentoftheSAGAcomplex,toformH2A.ZK3Ac,H2A.ZK8Ac,H2A.ZK10AcandH2A.ZK14Aconcedepositedintochromatin.Acetylationisrequiredforfunctionattelomeres.H2A.ZK14Acisacetylatedatthepromotersofactivegenes. MISCELLANEOUS:Presentwith2840molecules/cellinlogphaseSDmedium. IncontrasttoH2A1andH2A2,appearstobeweaklyornotsumoylated. SEQUENCESIMILARITIES:BelongstothehistoneH2Afamily. CAUTION:Toensureconsistencybetweenhistoneentries,wefollowthe"Brno"nomenclatureforhistonemodifications,withpositionsreferingtothoseusedintheliteratureforthe"closest"modelorganism.DuetoslightvariationsinhistonesequencesbetweenorganismsandtothepresenceofinitiatormethionineinUniProtKB/Swiss-Protsequences,theactualpositionsofmodifiedaminoacidsinthesequencegenerallydiffer.Inthisentrythefollowingconventionsareused:H2A.ZK3ac=acetylatedLys-4;H2A.ZK8ac=acetylatedLys-9;H2A.ZK10ac=acetylatedLys-11;H2A.ZK14ac=acetylatedLys-15.
MolecularWeight	~16kDaobserved.Slightlycross-reactingband~14kDa(HistoneH4)withTBS-T(01%).

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Millipore/07-770 | Anti-acetyl-Histone H2A.Z (Lys8) Antibody | 07-770/07-770/100 µg

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