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Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL

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貨號: 07-937

品牌: Millipore

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Description
CatalogueNumber	07-937
Description	Anti-HDAC7Antibody
AlternateNames	histonedeacetylase7 histonedeacetylase7A
BackgroundInformation	Histonedeacetylases(HDAC)areenzymesthatregulatestranscriptionbyselectivelydeacetylatingtheeta-aminogroupsoflysineslocatedneartheaminoterminiofcorehistoneproteins.EightmembersoftheHDACfamilyhavebeenidentified,dividedintotwoclasses.ClassIincludesHDAC-1,2,3and8whileClassIIincludesHDAC-4,5,6,and7.HumanHDAC7iscomposedof912aminoacidresidues.AlthoughHDAC7islocalizedmostlytothecellnucleus,itisalsofoundinthecytoplasm,suggestingnucleo-cytoplasmicshuttling.ThehistonedeacetylaseactivityofHDAC7mapstoaC-terminaldomainandisdependentoninteractionwithclassIHDACsinthenucleus.Itisanactivecomponentofdifferenttranscriptionalco-repressorcomplexesthatcanberecruitedtospecificpromoterregionsviainteractionswithtranscriptionfactors.HDAC7catalyzesremovalofacetyl-groupsfromacetyl-lysinesofhistones,resultinginatighterDNA-histoneinteraction.ThiscompactionofchromatinleadstotherepressionoftranscriptionofDNAinthatregion.

ProductInformation
Format	AffinityPurified
Control	RecombinantHDAC7protein(Cat.#14-832).
Presentation	PurifiedRabbitpolyclonalinbuffercontaining20mMPBSand0.1%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8oCfromdateofreceipt.

Applications
Application	UseAnti-HDAC7Antibody(RabbitPolyclonalAntibody)validatedinWBtodetectHDAC7alsoknownashistonedeacetylase7,histonedeacetylase7A.
KeyApplications	WesternBlotting
ApplicationNotes	WesternBlotting: ApreviouslotofthisantibodywasshowntorecognizerecombinantHDAC7butnotrecombinantHDAC1,HDAC4,orHDAC8. WesternBlotting: ApreviouslotofthisantibodywasshowntorecognizeendogenousHDAC7inHEK293Tcells.

BIOLOGicalInformation
Immunogen	Syntheticpeptidecorrespondingtoaminoacids164-182ofhumanHDAC7[(C)KPKKSLERRKNPLLRKESA].
Epitope	a.a.164-182
Host	Rabbit
Specificity	ThisantibodyrecognizeshumanHDAC7.Doesnotcross-reactwithHDAC1,HDAC4,orHDAC8.
SpeciesReactivity	Human
SpeciesReactivityNote	ReactswithHuman.Nottestedwithotherspecies.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001091886.1
EntrezGeneSummary	Histonesplayacriticalroleintranscriptionalregulation,cellcycleprogression,anddevelopmentalevents.Histoneacetylation/deacetylationalterschromosomestructureandaffectstranscriptionfactoraccesstoDNA.Theproteinencodedbythisgenehassequencehomologytomembersofthehistonedeacetylasefamily.ThisgeneisorthologoustomouseHDAC7genewhoseproteinpromotesrepressionmediatedviathetranscriptionalcorepressorSMRT.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.[providedbyRefSeq].
GeneSymbol	DKFZP586J0917 EC3.5.1.98 FLJ99588 HD7 HD7A HD7a HDAC7A
PurificationMethod	AffinityPurfied
UniProtNumber	Q8WUI4
UniProtSummary	FUNCTION:ResponsIBLeforthedeacetylationoflysineresiduesontheN-terminalpartofthecorehistones(H2A,H2B,H3andH4).Histonedeacetylationgivesatagforepigeneticrepressionandplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.InvolvedinmusclematurationbyrepressingtranscriptionofmyocyteenhancerfactorssuchasMEF2A,MEF2BandMEF2C.Duringmuscledifferentiation,itshuttlesintothecytoplasm,allowingtheexpressionofmyocyteenhancerfactorsBysimilarity.MaybeinvolvedinEpstein-Barrvirus(EBV)latency,possiblybyrepressingtheviralBZLF1gene. CatalyticactivityHydrolysisofanN(6)-acetyl-lysineresidueofahistonetoyieldadeacetylatedhistone. SUBUNIT:InteractswithHDAC1,HDAC2,HDAC3,HDAC4,HDAC5,NCOR1,NCOR2,SIN3A,SIN3B,RBBP4,RBBP7,MTA1L1,SAP30andMBD3.Interactswiththe14-3-3proteinYWHAE,MEF2A,MEF2BandMEF2CBysimilarity.InteractswithHTATIPandEDNRA.InteractswithJARID1B. SUBCELLULARLOCATION:Nucleus.Cytoplasm.Note=Inthenucleus,itassociateswithdistinctsubnucleardot-likestructures.Shuttlesbetweenthenucleusandthecytoplasm.TreatmentwithEDN1resultsinshuttlingfromthenucleustotheperinuclearregion.Theexporttocytoplasmdependsontheinteractionwiththe14-3-3proteinYWHAEandmaybeduetoitsphosphorylation. DOMAIN:ThenuclearexportsequencemediatestheshuttlingbetweenthenucleusandthecytoplasmBysimilarity. PTM:MaybephosphorylatedbyCaMK1Bysimilarity. MISCELLANEOUS:ItsactivityisinhibitedbyTrichostatinA(TSA),aknownhistonedeacetylaseinhibitorBysimilarity. SIMILARITY:Belongstothehistonedeacetylasefamily.Type2subfamily.
MolecularWeight	100kDa

PhysicochemicalInformation

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Millipore/07-937 | Anti-HDAC7 Antibody/07-937/100 µL

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