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Millipore/07-947 | Anti-dimethyl-Histone H4 (Arg3) Symmetric Antibody/07-947/100 µg

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貨號: 07-947

品牌: Millipore

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Description
CatalogueNumber	07-947
Description	Anti-dimethyl-HistoneH4(Arg3)SymmetricAntibody
AlternateNames	histone4,H4 histoneH4 histonecluster4,H4
BackgroundInformation	HistonesarehighlyconservedproteinsthatserveasthestructuralscaffoldfortheorganizationofnuclearDNAintochromatin.Thefourcorehistones,H2A,H2B,H3,andH4,assembleintoanoctamer(2moleculesofeach).Histonesaremodifiedpost-translationallybytheactionsofenzymesinboththenucleusandcytoplasm.Thesemodifications,whichincludeacetylation,phosphorylation,methylation,andubiquitin-ation,occurpredominantlyontheN-terminalandC-terminaltailsthatextendbeyondthenucleosomecoreparticle.Argininemodificationsofhistonesproteinsaremediatedbytwoclassesofproteinargininemethyltransferases(PRMTs),classIandII.ClassIPRMTsplacetwomethylgroupsontheonenitrogenatomofthearginineguanidinogroup,resultinginanasymmetricmodification.IncontrastclassIIPRMTsplacetwomethylgroupsontwonitrogenatomsoftheguanidinogroupproducingasymmetricdimethylation.Althoughthereareexceptions,asymmetricmodificationsaretypicallyassociatedwithtranscriptionactivationwhilesymmetricmodificationsaremostcommonlyassociatedwithtranscriptionalrepression.

ProductInformation
Format	AffinityPurified
Control	HeLaacidextract
Presentation	Purifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4),150mMNaClwith0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8°Cfromdateofreceipt.

Applications
Application	UseAnti-dimethyl-HistoneH4(Arg3)SymmetricAntibody(rabbitpolyclonalantibody)validatedinWB,ICC,DBtodetectdimethyl-HistoneH4(Arg3)SymmetricalsoknownashistoneH4,histonecluster4H4.
KeyApplications	WesternBlotting Immunocytochemistry DotBlot
ApplicationNotes	ImmunocytochemistryAnalysis:1:500dilutionfromarepresentativelotdetectedHistoneH4inHeLaandA431cells. PeptideDotBlotAnalysis:0.5μg/mLofthisantibodydetectedHistoneH4dimethylArg3(symmetric)peptides,butdidnotdetectHistoneH4dimethylArg3(assymmetric)peptide,othermodifiedpeptides,ornon-methyatedhistoneH4peptides.

BIOLOGicalInformation
Immunogen	KLH-conjugatedlinearpeptidecorrespondingtohumanHistoneH4whensymmetricallydimethylatedatArg3.
Epitope	SymmetricallydimethylatedArg3
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Rabbit
Specificity	ThisantibodyrecognizesHistoneH4symmetricallydimethylatedatArg3.
SpeciesReactivity	Human Mouse Rat
SpeciesReactivityNote	Demonstratedtoreactwithhuman,mouse,andrat.Broadspeciescross-reactivityexpectedbasedonsequencesimilarity.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NP_001029249
EntrezGeneSummary	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Thisstructureconsistsofapproximately146bpofDNAwrappedaroundanucleosome,anoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.ThisgeneisintronlessandencodesamemberofthehistoneH4family.TranscriptsfromthisgenelackpolyAtails;instead,theycontainapalindromicterminationelement.Thisgeneisfoundinahistoneclusteronchromosome1.Thisgeneisoneoffourhistonegenesintheclusterthatareduplicated;thisrecordrepresentsthetelomericcopy.[providedbyRefSeq].
GeneSymbol	HIST1H4A H4/J HIST1H4F HIST1H4L H4FN H4FA H4FH HIST1H4H H4F2 H4FM H4/A H4FK H4FG HIST2H4 H4FB H4/K HIST1H4I H4/N HIST1H4B H4FE H4/M H4/a HIST1H4E HIST4H4 HIST2H4A H4FC H4FI H4/H HIST1H4C H4/G HIST1H4K H4FJ H4FD H4/I H4/B H4/D H4/C HIST1H4J HIST1H4D H4/E
Modifications	Methylation
PurificationMethod	AffinityPurfied
UniProtNumber	P62805
UniProtSummary	FUNCTION:Corecomponentofnucleosome.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstABIlity.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling. SUBUNITSTRUCTURE:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA. SUBCELLULARLOCATION:Nucleus.Chromosome. PTM:AcetylationatLys-6(H4K5ac),Lys-9(H4K8ac),Lys-13(H4K12ac)andLys-17(H4K16ac)occursincodingregionsofthegenomebutnotinheterochromatin. CitrullinationatArg-4(H4R3ci)byPADI4impairsmethylation. MonomethylationatArg-4(H4R3me1)byPRMT1favorsacetylationatLys-9(H4K8ac)andLys-13(H4K12ac).DemethylationisperformedbyJMJD6. SymmetricdimethylationonArg-4(H4R3me2a)bythePRDM1/PRMT5complexmayplayacrucialroleinthegerm-celllineage. Monomethylated,dimethylatedortrimethylatedatLys-21(H4K20me1,H4K20me2,H4K20me3).MonomethylationisperformedbySET8.TrimethylationisperformedbySUV420H1andSUV420H2andinducesgenesilencing. UbiquitinatedbytheCUL4-DDB-RBX1complexinresponsetoultravioletirradiation.ThismayweakentheinteractionbetweenhistonesandDNAandfacilitateDNAaccessibilitytorepairproteins.MonoubiquitinatedatLys-92ofhistoneH4(H4K91ub1)inresponsetoDNAdamage.TheexactroleofH4K91ub1inDNAdamageresponseisstillunclearbutitmayfunctionasalicensingsignalforadditionalhistoneH4post-translationalmodificationssuchasH4Lys-21methylation(H4K20me). Sumoylated,whichisassociatedwithtranscriptionalrepression. SEQUENCESIMILARITIES:BelongstothehistoneH4family. SEQUENCECAUTION:ThesequenceAAI28106.1differsfromthatshown.Reason:Frameshiftatposition3.
MolecularWeight	~13kDaobserved.Crossreactingbandat~58kDahasbeenobservedinsomelysates.

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Millipore/07-947 | Anti-dimethyl-Histone H4 (Arg3) Symmetric Antibody/07-947/100 µg

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