| Immunogen | KLHconjugatedsyntheticpeptidecorrespondingtoaminoacidssurroundingTyr284ofhumanACK1. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | RecognizesACK1phosphorylatedonTyrosineresidue284. |
| Isotype | IgG |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThisgeneencodesatyrosinekinasethatbindsCdc42HsinitsGTP-boundformandinhibitsboththeintrinsicandGTPase-activatingprotein(GAP)-stimulatedGTPaseactivityofCdc42Hs.Thisbindingismediatedbyauniquesequenceof47aminoacidsC-terminaltoanSH3domain.TheproteinmaybeinvolvedinaregulatorymechanismthatsustainstheGTP-boundactiveformofCdc42Hsandwhichisdirectlylinkedtoatyrosinephosphorylationsignaltransductionpathway.Severalalternativelysplicedtranscriptvariantshavebeenidentifiedfromthisgene,butthefull-lengthnatureofonlytwotranscriptvariantshasbeendetermined. |
| GeneSymbol | - TNK2
- p21cdc42Hs
- ACK1
- ACK-1
- FLJ45547
- FLJ44758
- ACK
|
| Modifications | |
| PurificationMethod | ImmunoAffinityPurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q07912#DownstreameffectorofCDC42whichmediatesCDC42-dependentcellmigrationviaphosphorylationofBCAR1.Bindstobothpoly-andmono-ubiquitinandregulatesligand-induceddegradationofEGFR.Participatesinclathrin-mediatedendocytosis.Maybeinvolvedbothinadultsynapticfunctionandplasticityandinbraindevelopment. COFACTOR:Magnesium. SIZE:1036aminoacids;114327Da SUBUNIT:InteractswithCDC42.InteractswithactivatedCSPG4. SUBCELLULARLOCATION:Cellmembrane(Bysimilarity). SIMILARITY:SwissProt:Q07912##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.&Contains1CRIBdomain.&Contains1proteinkinasedomain.&Contains1SH3domain. |
| MolecularWeight | 114kDa |