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Millipore/09-310 | Anti-phospho-EGFR (Tyr1069) Antibody/09-310/100 µL

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貨號: 09-310

品牌: Millipore

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Description
CatalogueNumber	09-310
Replaces	04-339
Description	Anti-phospho-EGFR(Tyr1069)Antibody
AlternateNames	Receptortyrosine-proteinkinaseErbB-1 avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog cellgrowthinhibitingprotein40 cellproliferation-inducingprotein61 epidermalgrowthfactorreceptor epidermalgrowthfactorreceptor(avianerythroblasticleukemiaviral(v-erb-b)oncogenehomolog) epidermalgrowthfactorreceptor(erythroblasticleukemiaviral(v-erb-b)oncogenehomolog,avian)
BackgroundInformation	EGFR(Epidermalgrowthfactorreceptor,ErbB-1)isareceptortyrosinekinase(RTK)thatisoneoffourmembersoftheEGFR/ErbBfamilyofreceptortyrosinekinases.EGFRplaysakeyroleintheregulationofessentialnormalcellularprocessesandinthepathophysiologyofhyperproliferativediseasessuchascancer.ActivationoftheEGFRsignalingpathwayhasbeenlinkedwithincreasedcellproliferation,angiogenesis,metastasisanddecreasedapoptosis.Uponligandbinding,EGFRundergoesatransitionfromaninactivemonomericformtoanactivedimer.Inadditiontoforminghomodimers,EGFRmaypairwithanothermemberoftheErbBreceptorfamily,suchasErbB2/Her2/neu,tocreateanactivatedheterodimer.EGFRdimerizationstimulatesitsintrinsicintracellularprotein-tyrosinekinaseactivitythatleadstotrans-andauto-phosphorylationoftyrosineresidueswithinthecytoplasmicdomainofthereceptortyrosinekinaseoffivetyrosine(Y)residuesonsitesY992,Y1045,Y1068,Y1148andY1173locatedontheC-terminaldomainofEGFR.Thisautophosphorylationelicitsdownstreamactivationofseveralsignaltransductioncascades,principallytheMAPK,AktandJNKpathwaysthroughRas,PI3Kinase,andPLCpathwaysthatultimatelyleadstotheactivationofthevariouspathwaysdownstream.Tyr1069isphosphorylatedduringactivation.

ProductInformation
Format	AffinityPurified
Control	UntreatedandEGFtreatedA431lysates
Presentation	Antigenaffinitypurifiedrabbitpolyclonalin0.1MTris-Glycine(pH7.4)150mMNaCl,with0.05%sodiumazide.

StorageandShippingInformation
StorageConditions	Stablefor1yearat2-8oCinundilutedaliquotsfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.

Applications
Application	ThisAnti-phospho-EGFR(Tyr1069)AntibodyisvalidatedforuseinELISA,IC,WBforthedetectionofphospho-EGFR(Tyr1069).
KeyApplications	ELISA Immunocytochemistry WesternBlotting
ApplicationNotes	ImmunofluroescentImmunocytochemistry:

BIOLOGicalInformation
Immunogen	Tyrosine-phosphorylatedepidermalgrowthfactorreceptor.
Epitope	Tyr1069(cytoplasmicdomain)
Host	Rabbit
Specificity	ReactsstronglyandspecificallywithTyr1069phosphorylatedEGFR
SpeciesReactivity	Human Mouse Pig Primate Horse Rat
SpeciesReactivityNote	TestedinHuman.Expectedtoreactwithmouse,rat,primate,horseandpigbasedon100%sequencehomology.
AntibodyType	PolyclonalAntibody
EntrezGeneNumber	NM_005228.3
EntrezGeneSummary	Theproteinencodedbythisgeneisatransmembraneglycoproteinthatisamemberoftheproteinkinasesuperfamily.Thisproteinisareceptorformembersoftheepidermalgrowthfactorfamily.EGFRisacellsurfaceproteinthatbindstoepidermalgrowthfactor.Bindingoftheproteintoaligandinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation.Mutationsinthisgeneareassociatedwithlungcancer.[providedbyRefSeq]
GeneSymbol	ERBB ERBB1 HER1 PIG61 mENA EC2.7.10.1
Modifications	Phosphorylation
PurificationMethod	AntigenAffinityPurified
UniProtNumber	P00533
UniProtSummary	FUNCTION:ReceptorforEGF,butalsoforothermembersoftheEGFfamily,asTGF-alpha,amphiregulin,betacellulin,heparin-bindingEGF-likegrowthfactor,GP30andvacciniavirusgrowthfactor.Isinvolvedinthecontrolofcellgrowthanddifferentiation.PhosphorylatesMUC1inbreastcancercellsandincreasestheinteractionofMUC1withC-SRCandCTNNB1/beta-catenin.Ref.32 Isoform2/truncatedisoformmayactasanantagoNIST.Ref.32 CatalyticactivityATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate. SUBUNIT:BindsRIPK1.CBLinteractswiththeautophosphorylatedC-terminaltailoftheEGFreceptor.PartofacomplexwithERBB2andeitherPIK3C2AorPIK3C2B.TheautophosphorylatedforminteractswithPIK3C2B,maybeindirectly.InteractswithPELP1.BindsMUC1.Ref.32Ref.26Ref.30Ref.31Ref.36 SUBCELLULARLOCATION:Cellmembrane;Single-passtypeImembraneprotein. Isoform2:Secreted. TISSUESPECIFICITY:Ubiquitouslyexpressed.Isoform2isalsoexpressedinovariancancers.Ref.39 PTM:PhosphorylationofSer-695ispartialandoccursonlyifThr-693isphosphorylated.Ref.17Ref.25Ref.29Ref.33Ref.34Ref.35Ref.37Ref.38Ref.40Ref.41Ref.42Ref.43 MonoubiquitinatedandpolyubiquitinateduponEGFstimulation;whichdoesnotaffecttyrosinekinaseactivityorsignalingcapacitybutmayplayaroleinlysosomaltargeting.Polyubiquitinlinkageismainlythrough"Lys-63",butlinkagethrough"Lys-48","Lys-11"and"Lys-29"alsooccur. DISEASE:DefectsinEGFRareassociatedwithlungcancer[MIM:211980]. MiscellaneousBindingofEGFtothereceptorleadstodimerization,internalizationoftheEGF-receptorcomplex,inductionofthetyrosinekinaseactivity,stimulationofcellDNAsynthesis,andcellproliferation. SIMILARITY:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.EGFreceptorsubfamily. Contains1proteinkinasedomain.
MolecularWeight	~170kDa

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Millipore/09-310 | Anti-phospho-EGFR (Tyr1069) Antibody/09-310/100 µL

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