CASNumber114-07-8
EmpiricalFormula(HillNotation)C37H67NO13
MolecularWeight733.93
BeilsteinRegistryNumber75279
MDLnumberMFCD00084654
PubChemSubstanceID329749382
Properties:
| RelatedCategories | AnalyticalStandards,Analytical/Chromatography,Pharmacopeia&MetrologicalInstitutesStandards,USPStandards,USPStandardsE-F |
Description:
Application
ErythromycinisanantibioticproducedbygrowthofcertainstrainsofStreptomyceserythreus.ThisproductiscomposedlargelyoferythromycinAwithsmallamountsoferythromycinsBandCandisrecommendedforconcentrationat100mg/L.Concentrationsbetween50and200mg/Lhavealsoproveneffectiveincontrollingbacterialgrowth.ErythromycinhasbeenusedasamotilinreceptoragoNIST,toblockrespiratoryglycoconjugatesecretioninhumanairwaysinvitro,andforselectingplasmid-curedandrecombinantlactococcuslactisMG1363strains.
Biochem/physiolActions
ModeofAction:Erythromycinactsbyinhibitingelongationatthetranspeptidationstep,specificallyaminoacyltranslocationfromtheA-sitetoP-sitebybindingtothe50ssubunitofthebacterial70srRNAcomplex.
AntimicrobialSpectrum:Thisproductactsagainstbothgram-negativeandgram-positivebacteria.
Caution
Thisproductisstableinsolutionat37°Cfor3days.Stocksolutionsshouldbestoredat2-8°C.
OtherNotes
USPissuedSDScanbefoundhere
.
PreparationNote
Thisproductissolubleinwaterat2mg/mL,witha0.067%solutioninwateryieldingapHof8.0-10.5.Itisalsosolubleinethanolat50mg/mL,yieldingaclear,colorlesstofaintyellowsolution.Itisfreelysolubleinalcohol,acetone,chloroform,acetonitrileandethylacetatebutformssaltswithacids.Allsolutionsshouldbeprotectedfromlight.
LegalInformation
ThisproductisprovidedasdeliveredandspecifiedbytheissuingPharmacopoeia.Allinformationprovidedinsupportofthisproduct,includingSDSandanyproductinformationleafletshavebeendevelopedandissuedundertheAuthorityoftheissuingPharmacopoeia.ForfurtherinformationandsupportpleasegotothewebsiteoftheissuingPharmacopoeia
.
Safety:
RIDADR
NONHforallmodesoftransport