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CASNumber1400-61-9
MDLnumberMFCD25541651
PubChemSubstanceID329750594
| RelatedCategories | AnalyticalStandards,Analytical/Chromatography,Pharmacopeia&MetrologicalInstitutesStandards,USPStandards,USPStandardsN-O |
Nystatinisapolyeneantibiotic.Itsusesincludepreventingcellculturecontaminationandinducinginterleukin(IL)-1,IL-8,andtumornecrosisfactorasecretioninTLR2-expressingTHP1cells.Thisproductisrecommendedforuseincellcultureapplicationsat50mg/L.
ModeofAction:Nystatinactsbybindingtoergosterolsinfungalcellmembranes,increasingpermeABIlityofthemembrane,andcreatingnystatin/ergosterolbasedionchannels.Italsofunctionsasalipidraft-inhibitingreagentandasmembraneassociatedcholesterol.
Antimicrobialspectrum:Neomycinactsagainstfungi,yeastsandmolds.
Nystatinintissueculuturemediaisstableat37°Cforthreedays.Itisalsostableinmoderatelyalkalinemedia.Solutionsandaqueoussuspensionsbegintoloseactivitysoonafterpreparation,withheat,light,andoxygenacceleratingthedecomposition.Aqueoussuspensionsarestablefor10minuteswhenheatingto100°CatpH7.
Nystatinissolubleat28°Cinmethanol(11.2mg/mL),ethanol(1.2mg/mL),carbontetrachloride(1.23mg/mL),chloroform(0.48mg/mL),benzene(0.28mg/mL),andethyleneglycol(8.75mg/mL).ItisalsosolubleinDMSOat5mg/mLandfreelysolubleinDMFandformamide.ItisnotrecommendedtoautoclaveorsterilefiltersolutionsofNystatin.Nystatinisalsoeffectiveasasuspension,stableat37°Cfor3days.Prepare50mg/mLstocksuspensionsinwaterandstoreat-20°C.?
USPissuedSDScanbefoundhere.
ThisproductisprovidedasdeliveredandspecifiedbytheissuingPharmacopoeia.Allinformationprovidedinsupportofthisproduct,includingSDSandanyproductinformationleafletshavebeendevelopedandissuedundertheAuthorityoftheissuingPharmacopoeia.ForfurtherinformationandsupportpleasegotothewebsiteoftheissuingPharmacopoeia.
