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Millipore/15-101 | Akt phosphorylation Pathway Explorer MiniPack/15-101/3 vials/Pk

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貨號: 15-101

品牌: Millipore

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Description
CatalogueNumber	15-101
BrandFamily	Upstate
TradeName	Upstate
Description	AktphosphorylationPathwayExplorerMiniPack
AlternateNames	ProteinkinaseB RAC-alphaserine/threonine-proteinkinase racproteinkinasealpha v-aktmurinethymomaviraloncogenehomolog1 murinethymomaviral(v-akt)oncogenehomolog-1
BackgroundInformation	PathwayExplorerAntibodyMiniPack: EachPathwayExplorerAntibodyMinipackcontainsthreerelatedantibodiesaspartofasignalingcascadeoracombinationoftotalandphosphorylatedformsofkeysignalingtargets.Eachofthethreeantibodiesare30%theoriginalpacksize.FullsizeversionsofeachofthePathwayExplorerantibodiesareavailableforsaleindividuallyunderthesamecatalognumberwiththeremovalof“SP”offofeachone(e.g.05-591SPcanbeorderedas05-591). Anti-Akt/PKB,PHDomain, cloneSKB1: Akt(proteinkinaseB),aserine/threoninekinase,hasemergedasacriticalenzymeinsignaltransductionpathwaysinvolvedincellproliferation,apoptosis,angiogenesis,anddiabetes.InmammalsthreeisoformsofAkt(α,β,γorAkt1,2,3)arereportedthatexhibitahighdegreeofhomology,butdifferslightlyinthelocalizationoftheirregulatoryphosphorylationsites.Aktαisthepredominantisoforminmosttissues,whereasthehighestexpressionofAktβisobservedintheinsulin-responsivetissues,andAktγisabundantinbraintissue.EachAktisoformiscomposedofthreefunctionallydistinctregions:anN-terminalpleckstrinhomology(PH)domainthatprovidesalipid-bindingmoduletodirectAkttoPIP3,acentralcatalyticdomain,andaC-terminalhydrophobicmotif. Anti-phospho-Akt(Thr308), clone50-1C-25orAnti-phospho-Akt1/PKBα(Ser473),clone11E6: Akt/PKBisaSer/ThrkinaseandamajorknowneffecterofthePI3Kinasepathway.ItisinvolvedinmultiplesignalingpathwaysthatrelatetomanyBIOLOGicalprocessesincludingmetabolism,apoptosis,cellcyclecontrol,angiogenesis,differentiation,andcellgrowthandproliferation.Inmammals,threeisoformsofAkt(Akt1/PKCα,Akt2/PKBβ,andAkt3/PKBγ)exists.Theyexhibitahighdegreeofhomology,butdifferslightlyinthelocalizationoftheirregulatoryphosphorylationsites.Akt1isthepredominantisoformthatisinmosttissuesandisthoughttohaveadominantroleingrowth,survival,embryonicdevelopment,andADIpocytedifferentiation.Akt2iscorrelatedwiththeregulationofglucosehomeostasisandisthepredominantisoformexpressedininsulin-responsivetissues.Akt3isabundantinbraintissue.EachAktisoformiscomposedofthreefunctionallydistinctregions:anN-terminalPleckstrinHomology(PH)domainthatprovidesalipid-bindingmodule,acentralcatalyticdomaincontainingThr308,andaC-terminalhydrophobicmotifcontainingSer473.TheactivationofAKTisdependentonadualregulatorymechanismthatrequiresbothitstranslocationtotheplasmamembraneanddualphosphorylationonThr308andSer473byPDK1andtheTORC2complex,respectively. *Seefullsizeversionsforcorrespondingreferences.

ProductInformation
Components	05-591SPAnti-Akt/PKB,PHDomain, cloneSKB1 05-802RSPAnti-phospho-Akt(Thr308), clone50-1C-25 05-669SPAnti-phospho-Akt1/PKBα(Ser473),clone11E6
Presentation	3individualtubescontainingeitherAnti-Akt/PKB,PHDomain,cloneSKB1;Anti-phospho-Akt(Thr308),clone50-1C-25;orAnti-phospho-Akt1/PKBα(Ser473),clone11E6
Properties	Eachvialis30%thesizeoftheparentcatalognumber

StorageandShippingInformation

Applications
Application	ThisAntibodypackcontainsAnti-Akt/PKBAntibody,PHDomain,Anti-phospho-AktAntibody(Thr308),Anti-phospho-Akt1/PKBαAntibody(Ser473).

BiologicalInformation
EntrezGeneNumber	NP_001014431
GeneSymbol	AKT C-AKT EC2.7.11.1 MGC99656 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA RAC-PK-alpha
UniProtNumber	P31749
UniProtSummary	FUNCTION:Generalproteinkinasecapableofphosphorylatingseveralknownproteins.PhosphorylatesTBC1D4.Signalsdownstreamofphosphatidylinositol3-kinase(PI(3)K)tomediatetheeffectsofvariousgrowthfactorssuchasplatelet-derivedgrowthfactor(PDGF),epidermalgrowthfactor(EGF),insulinandinsulin-likegrowthfactorI(IGF-I).Playsaroleinglucosetransportbymediatinginsulin-inducedtranslocationoftheGLUT4glucosetransportertothecellsurface.MediatestheantiapoptoticeffectsofIGF-I.Mediatesinsulin-stimulatedproteinsynthesis,partlybyplayingaroleinbothinsulin-inducedphosphorylationof4E-BP1andininsulin-inducedactivationofp70S6kinase.Promotesglycogensynthesisbymediatingtheinsulin-inducedactivationofglycogensynthase. CATALYTICACTIVITY:ATP+aprotein=ADP+aphosphoprotein. ENZYMEREGULATION:Threespecificsites,oneinthekinasedomain(Thr-308)andthetwootheronesintheC-terminalregulatoryregion(Ser-473andTyr-474),needtobephosphorylatedforitsfullactivation. SUBUNIT:InteractswithCENTG1isoform2(PIKE-A)inthepresenceofguaninenucleotides.TheC-terminusinteractswithCCDC88A/GRDNandTHEM4.InteractswithAKTIP.Interacts(viaPHdomain)withMTCP1,TCL1AANDTCL1B.InteractswithCDKN1B;theinteractionphosphorylatesCDKN1Bpromoting14-3-3bindingandcell-cycleprogression. SUBCELLULARLOCATION:Cytoplasm.Nucleus.Cellmembrane.Note=Nucleusafteractivationbyintegrin-linkedproteinkinase1(ILK1).NucleartranslocationisenhancedbyinteractionwithTCL1A. TISSUESPECIFICITY:Inallhumancelltypessofaranalyzed. DOMAIN:BindingofthePHdomaintothephosphatidylinositol3-kinasealpha(PI(3)K)resultsinitstargetingtotheplasmamembrane. DOMAIN:TheAGC-kinaseC-terminalmediatesinteractionwithTHEM4. PTM:PhosphorylationonThr-308,Ser-473andTyr-474isrequiredforfullactivity.Ser-473phosphorylationbytheRictor-mTorcomplexfavorsThr-308phosphorylationbyPDPK1.Ser-473phosphorylationisenhancedbyinteractionwithCENTG1isoform2(PIKE-A).Ser-473phosphorylationisenhancedinfocalcorticaldysplasiaswithTaylor-typeballooncells.

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Millipore/15-101 | Akt phosphorylation Pathway Explorer MiniPack/15-101/3 vials/Pk

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