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            當前位置 : Millipore >>> Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk
            Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk
            • Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk

            Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk

            價格: ¥2832.00 市場價: 4720.00

            貨號: 15-203
            品牌: Millipore
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              • Description
                CatalogueNumber15-203
                TradeName
                • Upstate
                DescriptionAlzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack
                BackgroundInformationPathwayInvestigatorAntibodyMiniPack:
                EachPathwayExplorerAntibodyMinipackcontainsthreerelatedantibodiesaspartofasignalingcascadeoracombinationoftotalandphosphorylatedformsofkeysignalingtargets.Eachofthethreeantibodiesare30%theoriginalpacksize.FullsizeversionsofeachofthePathwayExplorerantibodiesareavailableforsaleindividuallyunderthesamecatalognumberwiththeremovalof“SP”offofeachone(e.g.05-591SPcanbeorderedas05-591).

                AlzheimerPrecursorProteinA4,clone22C11:
                DepositsofamyloidproteininsenileplaquesnearnerveprocessesarefoundinthebrainsofagedhumandandcasesofAlzheimer"sDisease.Theprinciplecomponentofthisextracellularamyloidisbeta/A4,a4kDapeptidederivedfromalargeramyloidprecursorprotein(APP),whichiswidelyexpressedinthebrainandbody.Thecreation,transportandfunctionoftheseproteinsarecurrentlyunderinvestigation.

                14-3-3-eC-Terminus:
                Mammalsexpresssevendistinct14-3-3isoforms(gamma,epsilon,beta,zeta,sigma,theta,tau)thatformmultiplehomo-andhetero-dimmers,thusrendering14-3-3asakeymultifunctionalregulatorymolecule.14-3-3isomershavebeenimplicatedinseveralneurologicaldisorders:forexampleisoformsgamma,epsilonandbetaareexpressedinthecerebrospinalfluidofCreutzfeldt-Jakobpatients,butnotpatientssufferingfromotherneurologicalconditionssuchasAlzheimer"s.

                The14-3-3epsilon,C-terminalantibodyisoneofapanelofantibodiesthatweregeneratedagainst14-3-3isoformsandhavedemonstratedtheirpotentialforuseasanELISA-baseddiagnostictool.TheseantibodieswillallowtheresearchtoinvestigatetheroleofthisproteininkeycellularprocessesandneurologicaldisorderssuchasCreutzfeldt-Jakob,Alzheimer"sandParkinson"sDisease.

                *Seefullsizeversionsforcorrespondingreferences.
                ProductInformation
                Components
                • MAB348SP-Anti-AmyloidPrecursorProtein,cloneA4;15ug
                • AB9732SP-Anti-14-3-3-eC-terminus;30uL
                • AB9890SP-Anti-AGE;60uL
                Presentation3individualtubescontainingeitherAnti-AlzheimerPrecursorProteinA4,clone22C11;Anti-14-3-3epsilon,C-terminal;orAnti-AGE(AdvancedGlycationEnd-products)
                PropertiesEachvialis30%thesizeoftheparentcatalognumber
                StorageandShippingInformation
                Applications
                ApplicationAlzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack.
                BIOLOGicalInformation
                CrossReactivityVaries.SeeindividualDataSheets
                EntrezGeneNumber
                GeneSymbol
                • APP
                • PN-II
                • AD1
                • ABETA
                • CTFgamma
                • APPI
                • ABPP
                • A4
                • CVAP
                • PN2
                • PreA4
                • AAA
                • YWHAE
                • KCIP-1
                • MDS
                • 14-3-3E
                • MDCR
                • FLJ45465
                UniProtNumber
                UniProtSummaryFUNCTION:SwissProt:P62258#Adapterproteinimplicatedintheregulationofalargespectrumofbothgeneralandspecializedsignalingpathway.Bindstoalargenumberofpartners,usuallybyrecognitionofaphosphoserineorphosphothreoninemotif.Bindinggenerallyresultsinthemodulationoftheactivityofthebindingpartner.
                SIZE:255aminoacids;29174Da
                SUBUNIT:Homodimer.InteractswithNDEL1(Bysimilarity).InteractswithHCVcoreprotein.
                SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV.
                SIMILARITY:SwissProt:P62258##Belongstothe14-3-3family.
                PhysicochemicalInformation
                Dimensions
                MaterialsInformation
                MaterialsInformation
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