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Millipore/16-193 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, biotin conjugate/16-193/100 µg

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貨號: 16-193

品牌: Millipore

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Description
CatalogueNumber	16-193
BrandFamily	Upstate
TradeName	Upstate
Description	Anti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301,biotinconjugate
AlternateNames	H2AXS139P HistoneH2A.X(phosphoS139) H2Ahistonefamily,memberX H2AXhistone
BackgroundInformation	HistonesarebasicnuclearproteinsthatareresponsIBLeforthenucleosomestructureofthechromosomalfiberineukaryotes.Nucleosomesconsistofapproximately146bpofDNAwrappedaroundahistoneoctamercomposedofpairsofeachofthefourcorehistones(H2A,H2B,H3,andH4).Thechromatinfiberisfurthercompactedthroughtheinteractionofalinkerhistone,H1,withtheDNAbetweenthenucleosomestoformhigherorderchromatinstructures.

ProductInformation
Format	Biotin
Control	Staurosporine-treatedJurkatcelllysates.
Presentation	PurifiedbiotinconjugatedmousemonoclonalIgG1inbuffercontaining70%storagebuffer(0.02MPhosphatebuffer,pH7.6,0.25MNaCl,0.1%sodiumazide)and30%glycerol

StorageandShippingInformation
StorageConditions	Stablefor1yearat-20oCfromdateofreceipt. HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.Note:VariABIlityinfreezertemperaturesbelow-20°Cmaycauseglycerolcontainingsolutionstobecomefrozenduringstorage.

Applications
Application	Anti-phospho-HistoneH2A.X(Ser139)Antibody,cloneJBW301,biotinconjugateisaMouseMonoclonalAntibodyfordetectionofphospho-HistoneH2A.X(Ser139)alsoknownasH2AXS139P,H2AXhistone&hasbeenvalidatedinICC&WB.
KeyApplications	Immunocytochemistry WesternBlotting

BIOLOGicalInformation
Immunogen	KLH-conjugated,syntheticpeptide(CKATQA[pS]QEY)correspondingtoaminoacids134-142ofhumanhistoneH2A.X.Theimmunizingsequencehas8identicalaminoacidsinyeastandmouse.
Epitope	Ser139
Clone	JBW301
Concentration	PleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
Host	Mouse
Specificity	RecognizesHistoneH2A.XphosphorylatedatSer139,Mr15kDa.
Isotype	IgG1
SpeciesReactivity	Human
SpeciesReactivityNote	Human.Abroadspeciescross-reactivityisexpectedbasedonconservationofsequencehomology.
AntibodyType	MonoclonalAntibody
EntrezGeneNumber	NM_002105.2
EntrezGeneSummary	Histonesarebasicnuclearproteinsthatareresponsibleforthenucleosomestructureofthechromosomalfiberineukaryotes.Twomoleculesofeachofthefourcorehistones(H2A,H2B,H3,andH4)formanoctamer,aroundwhichapproximately146bpofDNAiswrappedinrepeatingunits,callednucleosomes.Thelinkerhistone,H1,interactswithlinkerDNAbetweennucleosomesandfunctionsinthecompactionofchromatinintohigherorderstructures.ThisgeneencodesamemberofthehistoneH2Afamily,andgeneratestwotranscriptsthroughtheuseoftheconservedstem-loopterminationmotif,andthepolyAadditionmotif.
GeneSymbol	H2AFX H2AX H2a/x H2A/X H2A.X
Modifications	Phosphorylation
PurificationMethod	ProteinGPurified
UniProtNumber	P16104
UniProtSummary	FUNCTION:SwissProt:P16104#VarianthistoneH2AwhichreplacesconventionalH2Ainasubsetofnucleosomes.NucleosomeswrapandcompactDNAintochromatin,limitingDNAaccessibilitytothecellularmachinerieswhichrequireDNAasatemplate.Histonestherebyplayacentralroleintranscriptionregulation,DNArepair,DNAreplicationandchromosomalstability.DNAaccessibilityisregulatedviaacomplexsetofpost-translationalmodificationsofhistones,alsocalledhistonecode,andnucleosomeremodeling.Requiredforcheckpoint-mediatedarrestofcellcycleprogressioninresponsetolowdosesofionizingrADIationandforefficientrepairofDNAdoublestrandbreaks(DSBs)specificallywhenmodifiedbyC-terminalphosphorylation. SIZE:143aminoacids;15145Da SUBUNIT:ThenucleosomeisahistoneoctamercontainingtwomoleculeseachofH2A,H2B,H3andH4assembledinoneH3-H4heterotetramerandtwoH2A-H2Bheterodimers.Theoctamerwrapsapproximately147bpofDNA.InteractswithnumerousproteinsrequiredforDNAdamagesignalingandrepairwhenphosphorylatedonSer-140.TheseincludeMDC1,TP53BP1,BRCA1andtheMRNcomplex,composedofMRE11A,RAD50,andNBN.InteractionwiththeMRNcomplexismediatedatleastinpartbyNBN.AlsointeractswithDHX9/NDHIIwhenphosphorylatedonSer-140. SUBCELLULARLOCATION:Nucleus. DEVELOPMENTALSTAGE:SynthesizedinG1aswellasinS-phase. DOMAIN:SwissProt:P16104The[ST]-QmotifconstitutesarecognitionsequenceforkinasesfromthePI3/PI4-kinasefamily. PTM:PhosphorylatedonSer-140(toformgamma-H2AFX)inresponsetoDNAdoublestrandbreaks(DSBs)generatedbyexogenousgenotoxicagentsandbystalledreplicationforks,andmayalsooccurduringmeioticrecombinationeventsandimmunoglobulinclassswitchinginlymphocytes.PhosphorylationcanextenduptoseveralthousandnucleosomesfromtheactualsiteoftheDSBandmaymarkthesurroundingchromatinforrecruitmentofproteinsrequiredforDNAdamagesignalingandrepair.Widespreadphosphorylationmayalsoservetoamplifythedamagesignaloraidrepairofpersistentlesions.PhosphorylationofSer-140inresponsetoionizingradiationismediatedbybothATMandPRKDCwhiledefectsinDNAreplicationinduceSer-140phosphorylationsubsequenttoactivationofATRandPRKDC.DephosphorylationofSer-140byPP2AisrequiredforDNADSBrepair.Inmeiosis,Ser-140phosphorylationmayoccuratsynaptonemalcomplexesduringleptoteneasanATM-dependentresponsetotheformationofprogrammedDSBsbySPO11.Ser-140phosphorylationmaysubsequentlyoccursatunsynapsedregionsofbothautosomesandtheXYbivalentduringzygotene,downstreamofATRandBRCA1activation.Ser-140phosphorylationmayalsoberequiredfortranscriptionalrepressionofunsynapsedchromatinandmeioticsexchromosomeinactivation(MSCI),wherebytheXandYchromosomescondenseinpachytenetoformtheheterochromaticXY-body.Duringimmunoglobulinclassswitchrecombinationinlymphocytes,Ser-140phosphorylationmayoccuratsitesofDNA-recombinationsubsequenttoactivationoftheactivation-inducedcytidinedeaminaseAICDA.&MonoubiquitinationofLys-120byRING1andRNF2/RING2complexgivesaspecifictagforepigenetictranscriptionalrepression(Bysimilarity). SIMILARITY:BelongstothehistoneH2Afamily.
MolecularWeight	15kDa

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Millipore/16-193 | Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301, biotin conjugate/16-193/100 µg

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