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CAS Number 64-75-5
Empirical Formula (Hill Notation) C22H24N2O8 · HCl
Molecular Weight 480.90
Beilstein Registry Number 3844873
E Number E701
EC Number 200-593-8
MDL number MFCD00078142
PubChem Substance ID 329753913
| Related Categories | Additional Standards, Analytical Standards, Analytical/Chromatography, Antibiotics Standards, Chromatography, |
| grade | analytical standard |
| InChI Key |
XMEVHPAGJVLHIG-FMZCEJRJSA |
| product line | VETRANAL™ |
| form | neat |
| shelf life | limited shelf life, expiry date on the label |
| application(s) | HPLC: suitable |
| gas chromatography (GC): suitable |
Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
This product should be frozen below 0°C and protected from light and moisture. In these conditions, the product has been shown to retain activity for 4 years. Stock solutions should be stored at -20°C and are stable at 37°C for 4 days.
The product is freely soluble in water, soluble in methanol and ethanol but is insoluble in ether and hydrocarbons. In water, the product yields a clear, yellow-orange solution with heating and in 95% ethanol, 50 mg dissolved in 4 mL with heating yields a clear, yellow-green solution. Tetracycline is rapidly destroyed by alkali hydroxide solutions and standing water solutions become turbid due to hydrolysis and precipitation. The potency of tetracycline is reduced in solutions with pH below 2.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
VETRANAL is a trademark of Sigma-Aldrich Co. LLC
GHS08, GHS09
