Sigma-Aldrich/Cyclosporin A/32425-100MG/100MG

• CAS Number 59865-13-3

• Empirical Formula (Hill Notation) C₆₂H₁₁₁N₁₁O₁₂

• Molecular Weight 1202.61

•  Beilstein Registry Number 3647785

•  MDL number MFCD00274558

•  PubChem Substance ID 329754203

Properties:

Description:

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

General description

Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.

Cyclosporin A has been used to:
• Prevent rejection of kidney and liver transplants.
• In graft versus host disease.
• Treatment of autoimmune diseases.
• Treatment of Schistosomiasis.

Legal Information

VETRANAL is a trademark of Sigma-Aldrich Co. LLC

Safety:

Symbol 

  GHS07, GHS08