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特別 提示
CAS Number 457639-26-8
Empirical Formula (Hill Notation) C18H16F3N3O2S
Molecular Weight 395.40
MDL number MFCD19443858
PubChem Substance ID 329755121
| Related Categories | Analytical Standards, Analytical/Chromatography, Opiates / Synthetic Analgesic Drug Standards, Pharmaceuticals, Illicit Drugs & Alcohol |
| grade | analytical standard |
| InChI Key |
NTFOSUUWGCDXEF-UHFFFAOYSA |
| product line | VETRANAL™ |
| form | neat |
| shelf life | limited shelf life, expiry date on the label |
| application(s) | HPLC: suitable |
| gas chromatography (GC): suitable |
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
VETRANAL is a trademark of Sigma-Aldrich Co. LLC
GHS06
